Metabolic and Cardiovascular Diseases

64. Inflammasome Activity in the Skeletal Muscle and Heart of Rodent Models for Duchenne Muscular Dystrophy. Int J Mol Sci. 2023 May 9;24(10):8497.

Onódi Z, Szabó PL, Kucsera D, Pokreisz P, Dostal C, Hilber K, Oudit GY, Podesser BK, Ferdinandy P, Varga ZV, Kiss A.
Journal/Proc./Book: International Journal of Molecular Sciences
Year: 2023
Thematic Pillar: Metabolic and Cardiovascular Diseases

63. Blue flash sheds light on the roles of individual phosphoserines in CFTR channel activation.

Csanády L.
Journal/Proc./Book: Journal of General Physiology
Year: 2023
Thematic Pillar: Metabolic and Cardiovascular Diseases

62. Spreading depolarization causes reperfusion failure after cerebral ischemia.

Törteli A, Tóth R, Berger S, Samardzic S, Bari F, Menyhárt Á, Farkas E.
Journal/Proc./Book: Acta neuropathologica communications
Year: 2023
Thematic Pillar: Metabolic and Cardiovascular Diseases

61.  HCN channels at the cell soma ensure the rapid electrical reactivity of fast-spiking interneurons in human neocortex.

Szegedi V, Bakos E, Furdan S, Kovács BH, Varga D, Erdélyi M, Barzó P, Szücs A, Tamás G, Lamsa K.
Journal/Proc./Book: PlOS Biology
Year:  2023
Thematic Pillar: Metabolic and Cardiovascular Diseases

60. BRAF RNA is prognostic and widely expressed in lung adenocarcinoma.

Dora D, Vörös I, Varga ZV, Takacs P, Teglasi V, Moldvay J, Lohinai Z.
Journal/Proc./Book: Translational Lung Cancer Research
Year:  2023
Thematic Pillar: Metabolic and Cardiovascular Diseases

59. Characterization of antibiotic resistomes by reprogrammed bacteriophage-enabled functional metagenomics in clinical strains.

Apjok G, Számel M, Christodoulou C, Seregi V, Vásárhelyi BM, Stirling T, Eszenyi B, Sári T, Vidovics F, Nagrand E, Kovács D, Szili P, Lantos II, Méhi O, Jangir PK, Herczeg R, Gálik B, Urbán P, Gyenesei A, Draskovits G, Nyerges Á, Fekete G, Bodai L, Zsindely N, Dénes B, Yosef I, Qimron U, Papp B, Pál C, Kintses B.
Journal/Proc./Book: Nature Microbiology
Year:  2023
Thematic Pillar: Immuno Inflammatory Diseases, Metabolic and Cardiovascular Diseases

58. Optimization of CFTR gating through the evolution of its extracellular loops.

Simon MA, Csanády L.
Journal/Proc./Book: Journal of General Physiology
Year:  2023
Thematic Pillar: Metabolic and Cardiovascular Diseases

57. Plasticity and stereotypic rewiring of the transcriptome upon bacterial evolution of antibiotic resistance.

Grézal G, Spohn R, Méhi O, Dunai A, Lázár V, Bálint B, Nagy I, Pál C, Papp B.

Journal/Proc./Book: Molecular Biology and Evolution
Year:  2023
Thematic Pillar: Immuno Inflammatory Diseases, Metabolic and Cardiovascular Diseases

56. Cardioprotective efficacy of limb remote ischemic preconditioning in rats: discrepancy between meta-analysis and a three-centre in vivo study.

Sayour NV, Brenner GB, Makkos A, Kiss B, Kovácsházi C, Gergely TG, Aukrust SG, Tian H, Zenkl V, Gömöri K, Szabados T, Bencsik P, Heinen A, Schulz R, Baxter GF, Zuurbier CJ, Vokó Z, Ferdinandy P, Giricz Z.

Journal/Proc./Book: Caridovascular Research
Year:  2023
Thematic Pillar: Metabolic and Cardiovascular Diseases

55. Protein Kinase D3 (PKD3) Requires Hsp90 for Stability and Promotion of Prostate Cancer Cell Migration.

Varga A, Nguyen MT, Pénzes K, Bátai B, Gyulavári P, Gurbi B, Murányi J, Csermely P, Csala M, Vántus T, Sőti C.

Journal/Proc./Book: Cells
Year:  2023
Thematic Pillar: Genomic Instability and Cancer

54. MiR-128-3p as blood based liquid biopsy biomarker in childhood acute lymphoblastic leukemia.

Rzepiel A, Horváth A, Kutszegi N, Gézsi A, Sági JC, Almási L, Egyed B, Lőrincz P, Visnovitz T, Kovács GT, Szalai C, Semsei ÁF, Erdélyi DJ.

Journal/Proc./Book: Molecular and Cellular Probes
Year:  2023
Thematic Pillar: Genomic Instability and Cancer

53. Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling.

Schoger E, Bleckwedel F, Germena G, Rocha C, Tucholla P, Sobitov I, Möbius W, Sitte M, Lenz C, Samak M, Hinkel R, Varga ZV, Giricz Z, Salinas G, Gross JC, Zelarayán LC.

Journal/Proc./Book: Communications Biology
Year:  2023
Thematic Pillar: Metabolic and Cardiovascular Diseases

52. IL-1β neutralization prevents diastolic dysfunction development, but lacks hepatoprotective effect in an aged mouse model of NASH.

Kucsera D, Tóth VE, Sayour NV, Kovács T, Gergely TG, Ruppert M, Radovits T, Fábián A, Kovács A, Merkely B, Ferdinandy P, Varga ZV.
Journal/Proc./Book: Scientific Reports
Year: 2023
Thematic Pillar: Metabolic and Cardiovascular Diseases

51. Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan.

Correia-Melo C, Kamrad S, Tengölics R, Messner CB, Trebulle P, Townsend S, Jayasree Varma S, Freiwald A, Heineike BM, Campbell K, Herrera-Dominguez L, Kaur Aulakh S, Szyrwiel L, Yu JSL, Zelezniak A, Demichev V, Mülleder M, Papp B, Alam MT, Ralser M.
Journal/Proc./Book: Cell
Year: 2023
Thematic Pillar: Metabolic and Cardiovascular Diseases

50. New targets and indications for probenecid

Onódi Z, Koch S, Rubinstein J, Ferdinandy P, Varga ZV.
Journal/Proc./Book: British Journal of Pharmacology
Year: 2022
Thematic Pillar: Metabolic and Cardiovascular Diseases

49. Dual amplification strategy turns TRPM2 channels into supersensitive central heat detectors.

Bartók Á, Csanády L.
Journal/Proc./Book: Proceedings of the National Academy of Sciences of the United States of America
Year: 2022
Thematic Pillar: Metabolic and Cardiovascular Diseases

48. Altered Cellular Protein Quality Control System Modulates Cardiomyocyte Function in Volume Overload-Induced Hypertrophy.

Gömöri K, Herwig M, Hassoun R, Budde H, Mostafi N, Delalat S, Modi S, Begovic M, Szabados T, Pipis J, Farkas-Morvay N, Leprán I, Kovács Á, Mügge A, Ferdinandy P, Görbe A, Bencsik P, Hamdani N.
Journal/Proc./Book: Atioxidants
Year: 2022
Thematic Pillar: Metabolic and Cardiovascular Diseases

47. Molecular characterization of immune checkpoint inhibitor-induced cardiotoxicity reveals IL-17A as a driver of cardiac dysfunction after anti-PD-1 treatment.

Gergely TG, Kucsera D, Tóth VE, Kovács T, Sayour NV, Drobni ZD, Ruppert M, Petrovich B, Ágg B, Onódi Z, Fekete N, Pállinger É, Buzás EI, Yousif LI, Meijers WC, Radovits T, Merkely B, Ferdinandy P, Varga ZV.
Journal/Proc./Book: British Journal of Pharmacology
Year: 2022
Thematic Pillar: Metabolic and Cardiovascular Diseases

46. A single early introduction governed viral diversity in the second wave of SARS-CoV-2 epidemic in Hungary.

Ari E, Vásárhelyi BM, Kemenesi G, Tóth GE, Zana B, Somogyi B, Lanszki Z, Röst G, Jakab F, Papp B, Kintses B.
Journal/Proc./Book: Database
Year: 2022
Thematic Pillar: Metabolic and Cardiovascular Diseases

45. TFLink: an integrated gateway to access transcription factor-target gene interactions for multiple species.

Liska O, Bohár B, Hidas A, Korcsmáros T, Papp B, Fazekas D, Ari E.
Journal/Proc./Book: Virus Evolution
Year: 2022
Thematic Pillar: Metabolic and Cardiovascular Diseases

44. Saxagliptin Cardiotoxicity in Chronic Heart Failure: The Role of DPP4 in the Regulation of Neuropeptide Tone.

Vörös I, Onódi Z, Tóth VÉ, Gergely TG, Sághy É, Görbe A, Kemény Á, Leszek P, Helyes Z, Ferdinandy P, Varga ZV.

Journal/Proc./Book: Biomedicines
Year: 2022
Thematic Pillar: Metabolic and Cardiovascular Diseases

43. Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe.

Gazzi T, Brennecke B, Atz K, Korn C, Sykes D, Forn-Cuni G, Pfaff P, Sarott RC, Westphal MV, Mostinski Y, Mach L, Wasinska-Kalwa M, Weise M, Hoare BL, Miljuš T, Mexi M, Roth N, Koers EJ, Guba W, Alker A, Rufer AC, Kusznir EA, Huber S, Raposo C, Zirwes EA, Osterwald A, Pavlovic A, Moes S, Beck J, Nettekoven M, Benito-Cuesta I, Grande T, Drawnel F, Widmer G, Holzer D, van der Wel T, Mandhair H, Honer M, Fingerle J, Scheffel J, Broichhagen J, Gawrisch K, Romero J, Hillard CJ, Varga ZV, van der Stelt M, Pacher P, Gertsch J, Ullmer C, McCormick PJ, Oddi S, Spaink HP, Maccarrone M, Veprintsev DB, Carreira EM, Grether U, Nazaré M.

Journal/Proc./Book: Chemical Science
Year: 2022
Thematic Pillar: Metabolic and Cardiovascular Diseases

42. Inflammasome activation in end-stage heart failure-associated atrial fibrillation.

Kugler S, Onódi Z, Ruppert M, Sayour AA, Oláh A, Benke K, Ferdinandy P, Merkely B, Radovits T, Varga ZV.

Journal/Proc./Book: ESC Heart Failure
Year: 2022
Thematic Pillar: Metabolic and Cardiovascular Diseases

41. Ca2+/calmodulin-dependent protein kinase II and protein kinase G oxidation contributes to impaired sarcomeric proteins in hypertrophy model.

Gömöri K, Herwig M, Budde H, Hassoun R, Mostafi N, Zhazykbayeva S, Sieme M, Modi S, Szabados T, Pipis J, Farkas-Morvay N, Leprán I, Ágoston G, Baczkó I, Kovács Á, Mügge A, Ferdinandy P, Görbe A, Bencsik P, Hamdani N.

Journal/Proc./Book: ESC Heart Fail
Year: 2022
Thematic Pillar: Metabolic and Cardiovascular Diseases

40. Gene loss and compensatory evolution promotes the emergence of morphological novelties in budding yeast

Farkas Z, Kovács K, Sarkadi Z, Kalapis D, Fekete G, Birtyik F, Ayaydin F, Molnár C, Horváth P, Pál C, Papp B.

Journal/Proc./Book: Nature Ecology and Evolution
Year: 2022
Thematic Pillar: Metabolic and Cardiovascular Diseases

39. Proteome-wide landscape of solubility limits in a bacterial cell.

Györkei Á, Daruka L, Balogh D, Őszi E, Magyar Z, Szappanos B, Fekete G, Fuxreiter M, Horváth P, Pál C, Kintses B, Papp B.
Journal/Proc./Book: Scientific reports
Year: 2022
Thematic Pillar: Immuno-inflammatory Diseases, Metabolic and Cardiovascular Diseases

38. Underground metabolism as a rich reservoir for pathway engineering.

Kovács SC, Szappanos B, Tengölics R, Notebaart RA, Papp B.
Journal/Proc./Book: Bioinformatics
Year: 2022
Thematic Pillar: Metabolic and Cardiovascular Diseases

37. PACAP-38 and PAC1 Receptor Alterations in Plasma and Cardiac Tissue Samples of Heart Failure Patients.

Szabó D, Sárszegi Z, Polgár B, Sághy É, Reglődi D, Tóth T, Onódi Z, Leszek P, Varga ZV, Helyes Z, Kemény Á, Ferdinandy P, Tamás A.
Journal/Proc./Book: International Journal of Molecular Sciences
Year: 2022
Thematic Pillar: Metabolic and Cardiovascular Diseases

36. Biocompatible poly(ethylene succinate) polyester with molecular weight dependent drug release properties.

Abdelghafour MM, Orbán Á, Deák Á, Lamch Ł, Frank É, Nagy R, Ziegenheim S, Sipos P, Farkas E, Bari F, Janovák L.
Journal/Proc./Book: Biomaterials
Year: 2022
Thematic Pillar: Metabolic and Cardiovascular Diseases

35. Questioning Glutamate Excitotoxicity in Acute Brain Damage: The Importance of Spreading Depolarization. Neurocrit Care.

Andrew RD, Farkas E, Hartings JA, Brennan KC, Herreras O, Müller M, Kirov SA, Ayata C, Ollen-Bittle N, Reiffurth C, Revah O, Robertson RM, Dawson-Scully KD, Ullah G, Dreier JP.
Journal/Proc./Book: Neurocritical care
Year: 2022
Thematic Pillar: Metabolic and Cardiovascular Diseases

34. Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions.

Császár E, Lénárt N, Cserép Cs, Környei Zs, Fekete R, Pósfai B, Balázsfi D, Hangya B, D. Schwarz A, Szabadits E, Szöllősi D, Szigeti K, Máthé D, L.Wset B, Sviatskó K, Brás A R, Mariani J-C, Kliever A, Lenkei Zs, Hricisák L, Benyó Z, Baranyi M, Sperlágh B, Menyhárt Á, Farkas E, Dénes Á.
Journal/Proc./Book: Journal of experimental medicine
Year: 2022
Thematic Pillar: Metabolic and Cardiovascular Diseases

33. Interplay of Oxidative Stress and Necrosis-like Cell Death in Cardiac Ischemia/Reperfusion Injury: A Focus on Necroptosis.

Adameova A, Horvath C, Abdul-Ghani S, Varga ZV, Suleiman MS, Dhalla NS.
Journal/Proc./Book: Biomedicines
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

32. Systematic transcriptomic and phenotypic characterization of human and murine cardiac myocyte cell lines and primary cardiomyocytes reveals serious limitations and low resemblances to adult cardiac phenotype. J Mol Cell Cardiol.

Onódi Z, Visnovitz T, Kiss B, Hambalkó S, Koncz A, Ágg B, Váradi B, Tóth VÉ, Nagy RN, Gergely TG, Gergő D, Makkos A, Pelyhe C, Varga N, Reé D, Apáti Á, Leszek P, Kovács T, Nagy N, Ferdinandy P, Buzás EI, Görbe A, Giricz Z, Varga ZV.
Journal/Proc./Book: Journal of Molecular and Cellular Cardiology
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

31. Transient Hypoperfusion to Ischemic/Anoxic Spreading Depolarization is Related to Autoregulatory Failure in the Rat Cerebral Cortex

Menyhárt Á, Varga DP, M Tóth O, Makra P, Bari F, Farkas E.
Journal/Proc./Book: Transient Hypoperfusion to Ischemic/Anoxic Spreading Depolarization is Related to Autoregulatory Failure in the Rat Cerebral Cortex.
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

30. Molecular pathology of the R117H cystic fibrosis mutation is explained by loss of a hydrogen bond.

Simon MA, Csanády L.
Journal/Proc./Book: eLife Sciences Publications
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

29. Somatostatin and Its Receptors in Myocardial Ischemia/Reperfusion Injury and Cardioprotection

Imre Vörös, Éva Sághy, Krisztina Pohóczky, András Makkos, Zsófia Onódi, Gábor B. Brenner, Tamás Baranyai, Bence Ágg, Barnabás Váradi, Ágnes Kemény, Przemyslaw Leszek, Anikó Görbe, Zoltán V. Varga, Zoltán Giricz, Rainer Schulz, Zsuzsanna Helyes, Péter Ferdinandy
Journal/Proc./Book: Frontiers in Pharmacology
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

28. SignaLink3: a multi-layered resource to uncover tissue-specific signaling networks

Luca Csabai, Dávid Fazekas, Tamás Kadlecsik, Máté Szalay-Bekő, Balázs Bohár, Matthew Madgwick, Dezső Módos, Márton Ölbei, Lejla Gul, Padhmanand Sudhakar, János Kubisch, Oyebode James Oyeyemi, Orsolya Liska, Eszter Ari, Bernadette Hotzi, Viktor A Billes, Eszter Molnár, László Földvári-Nagy, Kitti Csályi, Amanda Demeter, Nóra Pápai, Mihály Koltai, Máté Varga, Katalin Lenti, Illés J Farkas, Dénes Türei, Péter Csermely, Tibor Vellai, Tamás Korcsmáros
Journal/Proc./Book: Nucleic Acids Research
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

27. Molecular Network Approach Reveals Rictor as a Central Target of Cardiac ProtectomiRs

András Makkos, Bence Ágg, Zoltán V. Varga, Zoltán Giricz, Mariann Gyöngyösi, Dominika Lukovic, Rainer Schulz, Monika Barteková, Anikó Görbe, Péter Ferdinandy
Journal/Proc./Book: International Journal of Molecular Sciences
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

26. Degenerate but indispensable: how CFTR channel activity depends on the catalytically inactive ATP binding site?

László Csanády
Journal/Proc./Book: The Journal of Physiology
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

25. The Effect of Molecular Weight on the Solubility Properties of Biocompatible Poly(ethylene succinate) Polyester

Mohamed M. Abdelghafour, Ágoston Orbán, Ágota Deák, Łukasz Lamch, Éva Frank, Roland Nagy, Adél Ádám, Pál Sipos, Eszter Farkas, Ferenc Bari, László Janovák
Journal/Proc./Book: Polymers
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

24. Delayed Contralateral Nephrectomy Halted Post-Ischemic Renal Fibrosis Progression and Inhibited the Ischemia-Induced Fibromir Upregulation in Mice

Beáta Róka, Pál Tod, Tamás Kaucsár, Éva Nóra Bukosza, Imre Vörös, Zoltán V. Varga, Balázs Petrovich, Bence Ágg, Péter Ferdinandy, Gábor Szénási, Péter Hamar
Journal/Proc./Book: Biomedicines
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

23. Evidence of a Myenteric Plexus Barrier and its Macrophage-Dependent Degradation during Murine Colitis: Implications in Enteric Neuroinflammation

David Dora, Szilamer Ferenczi, Rhian Stavely, Viktoria E. Toth, Zoltan V. Varga, Tamas Kovacs, Ildiko Bodi, Ryo Hotta, Krisztina J. Kovacs, Allan M. Goldstein, Nandor Nagy
Journal/Proc./Book: Cellular and Molecular Gastroenterology and Hepatology
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

22. Bicarbonate Evokes Reciprocal Changes in Intracellular Cyclic di-GMP and Cyclic AMP Levels in Pseudomonas aeruginosa

Kasidid Ruksakiet, Balázs Stercz, Gergő Tóth, Pongsiri Jaikumpun, Ilona Gróf, Roland Tengölics, Zsolt M. Lohinai, Péter Horváth, Mária A. Deli, Martin C. Steward, Orsolya Dobay, Ákos Zsembery
Journal/Proc./Book: Biology
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

21. Systematic review and network analysis of microRNAs involved in cardioprotection against myocardial ischemia/reperfusion injury and infarction: Involvement of redox signalling

András Makkos, Bence Ágg, Balázs Petrovich, Zoltán V. Varga, Anikó Görbe, Péter Ferdinandy
Journal/Proc./Book: Free Radical Biology and Medicine
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

20. AIM2-driven inflammasome activation in heart failure

Zsófia Onódi, Mihály Ruppert, Dániel Kucsera, Alex Ali Sayour, Viktória E Tóth, Gábor Koncsos, Julianna Novák, Gábor B Brenner, András Makkos, Tamás Baranyai, Zoltán Giricz, Anikó Görbe, Przemyslaw Leszek, Mariann Gyöngyösi, Iván G Horváth, Rainer Schulz, Béla Merkely, Péter Ferdinandy, Tamás Radovits, Zoltán V Varga
Journal/Proc./Book: Cardiovascular Research
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

19. Two Decades of Evolution of Our Understanding of the Transient Receptor Potential Melastatin 2 (TRPM2) Cation Channel

Andras Szollosi
Journal/Proc./Book: Life
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

18. Balanced Intense Exercise Training Induces Atrial Oxidative Stress Counterbalanced by the Antioxidant System and Atrial Hypertrophy That Is Not Associated with Pathological Remodeling or Arrhythmogenicity

Attila Oláh, Bálint András Barta, Alex Ali Sayour, Mihály Ruppert, Eszter Virág-Tulassay, Julianna Novák, Zoltán V. Varga, Péter Ferdinandy, Béla Merkely, Tamás Radovits
Journal/Proc./Book: Antioxidants
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

17. Characterization of the CDAA Diet-Induced Non-alcoholic Steatohepatitis Model: Sex-Specific Differences in Inflammation, Fibrosis, and Cholesterol Metabolism in Middle-Aged Mice

Dániel Kucsera, Viktória E. Tóth, Dorottya Gergő, Imre Vörös, Zsófia Onódi, Anikó Görbe, Péter Ferdinandy, Zoltán V. Varga
Journal/Proc./Book: Frontiers in Physiology
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

16. Influence of cardiometabolic comorbidities on myocardial function, infarction, and CARDIOPROTECTION: Role of cardiac redox signaling

Ioanna Andreadou, Andreas Daiber, Gary F. Baxter, Maria.Felice Brizzi, Fabio di Lisa, Nina Kaludercic, Antigone Lazou, Zoltán.V. Varga, Coert Zuurbier, Rainer Schulz, Péter Ferdinandy
Journal/Proc./Book: Free Radical Biology and Medicine
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

15. PCSK9 in Myocardial Infarction and Cardioprotection: Importance of Lipid Metabolism and Inflammation

Ioanna Andreadou, Maria Tsoumani, Gemma Vilahur, Ignatios Ikonomidis, Lina Badimon, Zoltán V. Varga, Péter Ferdinandy, Rainer Schulz
Journal/Proc./Book: Frontiers in Physiology
Year: 2020
Thematic Pillar: Metabolic and Cardiovascular Diseases

14. Suboptimal global transcriptional response increases the harmful effects of loss-of-function mutations

Károly Kovács, Zoltán Farkas, Djordje Bajić, Dorottya Kalapis, Andreea Daraba, Karola Almási, Bálint Kintses, Zoltán Bódi, Richard A Notebaart, Juan F Poyatos, Patrick Kemmeren, Frank C P Holstege, Csaba Pál, Balázs Papp
Journal/Proc./Book: Molecular Biology and Evolution
Year: 2020
Thematic Pillar: Immuno-inflammatory Diseases,Metabolic and Cardiovascular Diseases

13. Characterization of Neurons Expressing the Novel Analgesic Drug Target Somatostatin Receptor 4 in Mouse and Human Brains

Angéla Kecskés, Krisztina Pohóczky, Miklós Kecskés, Zoltán V. Varga, Viktória Kormos, Éva Szőke, Nóra Henn-Mike, Máté Fehér, József Kun, Attila Gyenesei, Éva Renner, Miklós Palkovits, Péter Ferdinandy, István M. Ábrahám, Balázs Gaszner, Zsuzsanna Helyes
Journal/Proc./Book: International Journal of Molecular Sciences
Year: 2020
Thematic Pillar: Metabolic and Cardiovascular Diseases

12. Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells

Roman C. Sarott, Matthias V. Westphal, Patrick Pfaff, Claudia Korn, David A. Sykes, Thais Gazzi, Benjamin Brennecke, Kenneth Atz, Marie Weise, Yelena Mostinski, Pattarin Hompluem, Eline Koers, Tamara Miljuš, Nicolas J. Roth, Hermon Asmelash, Man C. Vong, Jacopo Piovesan, Wolfgang Guba, Arne C. Rufer, Eric A. Kusznir, Sylwia Huber, Catarina Raposo, Elisabeth A. Zirwes, Anja Osterwald, Anto Pavlovic, Svenja Moes, Jennifer Beck, Irene Benito-Cuesta, Teresa Grande, Samuel Ruiz de Martı́n Esteban, Alexei Yeliseev, Faye Drawnel, Gabriella Widmer, Daniela Holzer, Tom van der Wel, Harpreet Mandhair, Cheng-Yin Yuan, William R. Drobyski, Yurii Saroz, Natasha Grimsey, Michael Honer, Jürgen Fingerle, Klaus Gawrisch, Julian Romero, Cecilia J. Hillard, Zoltan V. Varga, Mario van der Stelt, Pal Pacher, Jürg Gertsch, Peter J. McCormick, Christoph Ullmer, Sergio Oddi, Mauro Maccarrone, Dmitry B. Veprintsev, Marc Nazaré, Uwe Grether, Erick M. Carreira
Journal/Proc./Book: Journal of the American Chemical Society
Year: 2020
Thematic Pillar: Metabolic and Cardiovascular Diseases

11. Anti-PD-1 Therapy Does Not Influence Hearing Ability in the Most Sensitive Frequency Range, but Mitigates Outer Hair Cell Loss in the Basal Cochlear Region

Judit Szepesy, Gabriella Miklós, János Farkas, Dániel Kucsera, Zoltán Giricz, Anita Gáborján, Gábor Polony, Ágnes Szirmai, László Tamás, László Köles, Zoltán V. Varga, Tibor Zelles
Journal/Proc./Book: International Journal of Molecular Sciences
Year: 2020
Thematic Pillar: Metabolic and Cardiovascular Diseases

10. Chronic treatment with rofecoxib but not ischemic preconditioning of the myocardium ameliorates early intestinal damage following cardiac ischemia/reperfusion injury in rats

Szilvia B. László, Bernadette Lázár, Gábor B. Brenner, András Makkos, Mihály Balogh, Mahmoud Al-Khrasani, Barbara Hutka, Amir Mohammadzadeh, Ágnes Kemény, Terézia László, Bálint Scheich, Tamara Szabados, Éva Kenyeres, Zoltán Giricz, Péter Bencsik, Zoltán V. Varga, Julianna Novák, Zsuzsanna Helyes, Péter Ferdinandy, Klára Gyires, Zoltán S. Zádori
Journal/Proc./Book: Biochemical Pharmacology
Year: 2020
Thematic Pillar: Metabolic and Cardiovascular Diseases

9. Cardiac miRNA Expression and their mRNA Targets in a Rat Model of Prediabetes

Éva Sághy, Imre Vörös, Bence Ágg, Bernadett Kiss, Gábor Koncsos, Zoltán V. Varga, Anikó Görbe, Zoltán Giricz, Rainer Schulz, Péter Ferdinandy
Journal/Proc./Book: International Journal of Molecular Sciences
Year: 2020
Thematic Pillar: Metabolic and Cardiovascular Diseases

8. Simple binding of protein kinase A prior to phosphorylation allows CFTR anion channels to be opened by nucleotides

Csaba Mihályi, Iordan Iordanov, Beáta Töröcsik, László Csanády
Journal/Proc./Book: Proceedings of the National Academy of Sciences
Year: 2020
Thematic Pillar: Metabolic and Cardiovascular Diseases

7. Limited Evolutionary Conservation of the Phenotypic Effects of Antibiotic Resistance Mutations

Gábor Apjok, Gábor Boross, Ákos Nyerges, Gergely Fekete, Viktória Lázár, Balázs Papp, Csaba Pál, Bálint Csörgő
Journal/Proc./Book: Molecular Biology and Evolution
Year: 2019
Thematic Pillar: Metabolic and Cardiovascular Diseases

6. Exploring the fitness benefits of genome reduction in Escherichia coli by a selection-driven approach

Viktor Vernyik, Ildikó Karcagi, Edit Tímár, István Nagy, Ádám Györkei, Balázs Papp, Zsuzsanna Györfy, György Pósfai
Journal/Proc./Book: Scientific Reports
Year: 2020
Thematic Pillar: Metabolic and Cardiovascular Diseases

5. Activity-based protein profiling of the human failing ischemic heart reveals alterations in hydrolase activities involving the endocannabinoid system

Annelot C.M. van Esbroeck, Zoltan V. Varga, Xinyu Di, Eva J. van Rooden, Viktória E. Tóth, Zsófia Onódi, Mariusz Kuśmierczyk, Przemyslaw Leszek, Péter Ferdinandy, Thomas Hankemeier, Mario van der Stelt, Pál Pacher
Journal/Proc./Book: Pharmacological Research
Year: 2019
Thematic Pillar: Metabolic and Cardiovascular Diseases

4. Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion

Anett Dunai, Réka Spohn, Zoltán Farkas, Viktória Lázár, Ádám Györkei, Gábor Apjok, Gábor Boross, Balázs Szappanos, Gábor Grézal, Anikó Faragó, László Bodai, Balázs Papp, Csaba Pál
Journal/Proc./Book: eLife
Year: 2019
Thematic Pillar: Metabolic and Cardiovascular Diseases

3. Unmatched level of molecular convergence among deeply divergent complex multicellular fungi

Zsolt Merényi, Arun N Prasanna, Zheng Wang, Károly Kovács, Botond Hegedüs, Balázs Bálint, Balázs Papp, Jeffrey P Townsend, László G Nagy
Journal/Proc./Book: Molecular Biology and Evolution
Year: 2019
Thematic Pillar: Metabolic and Cardiovascular Diseases

2. Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action

Bálint Kintses, Pramod K. Jangir, Gergely Fekete, Mónika Számel, Orsolya Méhi, Réka Spohn, Lejla Daruka, Ana Martins, Ali Hosseinnia, Alla Gagarinova, Sunyoung Kim, Sadhna Phanse, Bálint Csörgő, Ádám Györkei, Eszter Ari, Viktória Lázár, István Nagy, Mohan Babu, Csaba Pál, Balázs Papp
Journal/Proc./Book: Nature Communications
Year: 2019
Thematic Pillar: Immuno-inflammatory Diseases,Metabolic and Cardiovascular Diseases

1. Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance

Réka Spohn, Lejla Daruka, Viktória Lázár, Ana Martins, Fanni Vidovics, Gábor Grézal, Orsolya Méhi, Bálint Kintses, Mónika Számel, Pramod K. Jangir, Bálint Csörgő, Ádám Györkei, Zoltán Bódi, Anikó Faragó, László Bodai, Imre Földesi, Diána Kata, Gergely Maróti, Bernadett Pap, Roland Wirth, Balázs Papp, Csaba Pál
Journal/Proc./Book: Nature Communications
Year: 2019
Thematic Pillar: Immuno-inflammatory Diseases,Metabolic and Cardiovascular Diseases