Metabolic and Cardiovascular Diseases

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31. Systematic transcriptomic and phenotypic characterization of human and murine cardiac myocyte cell lines and primary cardiomyocytes reveals serious limitations and low resemblances to adult cardiac phenotype. J Mol Cell Cardiol.

Onódi Z, Visnovitz T, Kiss B, Hambalkó S, Koncz A, Ágg B, Váradi B, Tóth VÉ, Nagy RN, Gergely TG, Gergő D, Makkos A, Pelyhe C, Varga N, Reé D, Apáti Á, Leszek P, Kovács T, Nagy N, Ferdinandy P, Buzás EI, Görbe A, Giricz Z, Varga ZV.
Journal/Proc./Book: Journal of Molecular and Cellular Cardiology
Year: 2021
Thematic Pillar: Immuno-inflammatory Diseases / Metabolic and Cardiovascular Diseases

30. Molecular pathology of the R117H cystic fibrosis mutation is explained by loss of a hydrogen bond.

Simon MA, Csanády L.
Journal/Proc./Book: eLife Sciences Publications
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

29. Somatostatin and Its Receptors in Myocardial Ischemia/Reperfusion Injury and Cardioprotection

Imre Vörös, Éva Sághy, Krisztina Pohóczky, András Makkos, Zsófia Onódi, Gábor B. Brenner, Tamás Baranyai, Bence Ágg, Barnabás Váradi, Ágnes Kemény, Przemyslaw Leszek, Anikó Görbe, Zoltán V. Varga, Zoltán Giricz, Rainer Schulz, Zsuzsanna Helyes, Péter Ferdinandy
Journal/Proc./Book: Frontiers in Pharmacology (12)
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

28. SignaLink3: a multi-layered resource to uncover tissue-specific signaling networks

Luca Csabai, Dávid Fazekas, Tamás Kadlecsik, Máté Szalay-Bekő, Balázs Bohár, Matthew Madgwick, Dezső Módos, Márton Ölbei, Lejla Gul, Padhmanand Sudhakar, János Kubisch, Oyebode James Oyeyemi, Orsolya Liska, Eszter Ari, Bernadette Hotzi, Viktor A Billes, Eszter Molnár, László Földvári-Nagy, Kitti Csályi, Amanda Demeter, Nóra Pápai, Mihály Koltai, Máté Varga, Katalin Lenti, Illés J Farkas, Dénes Türei, Péter Csermely, Tibor Vellai, Tamás Korcsmáros
Journal/Proc./Book: Nucleic Acids Research
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

27. Molecular Network Approach Reveals Rictor as a Central Target of Cardiac ProtectomiRs

András Makkos, Bence Ágg, Zoltán V. Varga, Zoltán Giricz, Mariann Gyöngyösi, Dominika Lukovic, Rainer Schulz, Monika Barteková, Anikó Görbe, Péter Ferdinandy
Journal/Proc./Book: International Journal of Molecular Sciences (22/17)
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

26. Degenerate but indispensable: how CFTR channel activity depends on the catalytically inactive ATP binding site?

László Csanády
Journal/Proc./Book: The Journal of Physiology
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

25. The Effect of Molecular Weight on the Solubility Properties of Biocompatible Poly(ethylene succinate) Polyester

Mohamed M. Abdelghafour, Ágoston Orbán, Ágota Deák, Łukasz Lamch, Éva Frank, Roland Nagy, Adél Ádám, Pál Sipos, Eszter Farkas, Ferenc Bari, László Janovák
Journal/Proc./Book: Polymers (13/16)
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

24. Delayed Contralateral Nephrectomy Halted Post-Ischemic Renal Fibrosis Progression and Inhibited the Ischemia-Induced Fibromir Upregulation in Mice

Beáta Róka, Pál Tod, Tamás Kaucsár, Éva Nóra Bukosza, Imre Vörös, Zoltán V. Varga, Balázs Petrovich, Bence Ágg, Péter Ferdinandy, Gábor Szénási, Péter Hamar
Journal/Proc./Book: Biomedicines (9/7)
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

23. Evidence of a Myenteric Plexus Barrier and its Macrophage-Dependent Degradation during Murine Colitis: Implications in Enteric Neuroinflammation

David Dora, Szilamer Ferenczi, Rhian Stavely, Viktoria E. Toth, Zoltan V. Varga, Tamas Kovacs, Ildiko Bodi, Ryo Hotta, Krisztina J. Kovacs, Allan M. Goldstein, Nandor Nagy
Journal/Proc./Book: Journal of Investigative Dermatology
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

22. Negative trade-off between neoantigen repertoire breadth and the specificity of HLA-I molecules shapes antitumor immunity

Máté Manczinger, Balázs Koncz, Gergő Mihály Balogh, Benjamin Tamás Papp, Leó Asztalos, Lajos Kemény, Balázs Papp, Csaba Pál
Journal/Proc./Book: Nature Cancer
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases / Immuno-inflammatory Diseases

21. Bicarbonate Evokes Reciprocal Changes in Intracellular Cyclic di-GMP and Cyclic AMP Levels in Pseudomonas aeruginosa

Kasidid Ruksakiet, Balázs Stercz, Gergő Tóth, Pongsiri Jaikumpun, Ilona Gróf, Roland Tengölics, Zsolt M. Lohinai, Péter Horváth, Mária A. Deli, Martin C. Steward, Orsolya Dobay, Ákos Zsembery
Journal/Proc./Book: Biology (10/6)
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

20. Systematic review and network analysis of microRNAs involved in cardioprotection against myocardial ischemia/reperfusion injury and infarction: Involvement of redox signalling

András Makkos, Bence Ágg, Balázs Petrovich, Zoltán V. Varga, Anikó Görbe, Péter Ferdinandy
Journal/Proc./Book: Free Radical Biology and Medicine (72)
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

19. AIM2-driven inflammasome activation in heart failure

Zsófia Onódi, Mihály Ruppert, Dániel Kucsera, Alex Ali Sayour, Viktória E Tóth, Gábor Koncsos, Julianna Novák, Gábor B Brenner, András Makkos, Tamás Baranyai, Zoltán Giricz, Anikó Görbe, Przemyslaw Leszek, Mariann Gyöngyösi, Iván G Horváth, Rainer Schulz, Béla Merkely, Péter Ferdinandy, Tamás Radovits, Zoltán V Varga
Journal/Proc./Book: Cardiovascular Research
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

18. Alcohol in Psoriasis—From Bench to Bedside

Zita Szentkereszty-Kovács, Krisztián Gáspár, Andrea Szegedi, Lajos Kemény, Dóra Kovács, Dániel Törőcsik
Journal/Proc./Book: International Journal of Molecular Sciences (22/9)
Year: 2021
Thematic Pillar: Metabolic and Cardiovascular Diseases

17. Two Decades of Evolution of Our Understanding of the Transient Receptor Potential Melastatin 2 (TRPM2) Cation Channel

Andras Szollosi

Year: 2021

Thematic Pillar: Metabolic and Cardiovascular Diseases

16. Characterization of Neurons Expressing the Novel Analgesic Drug Target Somatostatin Receptor 4 in Mouse and Human Brains

Angéla Kecskés, Krisztina Pohóczky, Miklós Kecskés, Zoltán V. Varga, Viktória Kormos, Éva Szőke, Nóra Henn-Mike, Máté Fehér, József Kun, Attila Gyenesei, Éva Renner, Miklós Palkovits, Péter Ferdinandy, István M. Ábrahám, Balázs Gaszner, Zsuzsanna Helye

Year: 2021

Thematic Pillar: Metabolic and Cardiovascular Diseases

15. Influence of cardiometabolic comorbidities on myocardial function,
infarction, and CARDIOPROTECTION: Role of cardiac redox signaling

Ioanna Andreadou, Andreas Daiber, Gary F. Baxter, Maria.Felice Brizzi, Fabio di Lisa, Nina Kaludercic, Antigone Lazou, Zoltán.V. Varga, Coert Zuurbier, Rainer Schulz, Péter Ferdinandy

Year: 2021

Thematic Pillar: Metabolic and Cardiovascular Diseases

14. PCSK9 in Myocardial Infarction and Cardioprotection: Importance of Lipid Metabolism and Inflammation

Ioanna Andreadou, Maria Tsoumani, Gemma Vilahur, Ignatios Ikonomidis, Lina Badimon, Zoltán V. Varga, Péter Ferdinandy, Rainer Schulz
Journal/Proc./Book: Frontiers in Physiology (11)
Year: 2020
Thematic Pillar: Metabolic and Cardiovascular Diseases

13. Suboptimal global transcriptional response increases the harmful effects of loss-of-function mutations

Károly Kovács, Zoltán Farkas, Djordje Bajić, Dorottya Kalapis, Andrea Daraba, Karola Almási, Bálint Kintses, Zoltán Bódi, Richard A Notebaart, Juan F Poyatos, Patrick Kemmeren, Frank C P Holstege, Csaba Pál, Balázs Papp
Journal/Proc./Book: Molecular Biology and Evolution (-)
Year: 2020
Thematic Pillar: Metabolic and Cardiovascular Diseases

12. Characterization of Neurons Expressing the Novel Analgesic Drug Target Somatostatin Receptor 4 in Mouse and Human Brains

Journal/Proc./Book: International Journal of Molecular Sciences (21/20)
Year: 2020
Thematic Pillar: Metabolic and Cardiovascular Diseases

11. Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells

Roman C. Sarott, Matthias V. Westphal, Patrick Pfaff, Claudia Korn, David A. Sykes, Thais Gazzi, Benjamin Brennecke, Kenneth Atz, Marie Weise, Yelena Mostinski, Pattarin Hompluem, Eline Koers, Tamara Miljuš, Nicolas J. Roth, Hermon Asmelash, Man C. Vong, Jacopo Piovesan, Wolfgang Guba, Arne C. Rufer, Eric A. Kusznir, Sylwia Huber, Catarina Raposo, Elisabeth A. Zirwes, Anja Osterwald, Anto Pavlovic, Svenja Moes, Jennifer Beck, Irene Benito-Cuesta, Teresa Grande, Samuel Ruiz de Martı́n Esteban, Alexei Yeliseev, Faye Drawnel, Gabriella Widmer, Daniela Holzer, Tom van der Wel, Harpreet Mandhair, Cheng-Yin Yuan, William R. Drobyski, Yurii Saroz, Natasha Grimsey, Michael Honer, Jürgen Fingerle, Klaus Gawrisch, Julian Romero, Cecilia J. Hillard, Zoltan V. Varga, Mario van der Stelt, Pal Pacher, Jürg Gertsch, Peter J. McCormick, Christoph Ullmer, Sergio Oddi, Mauro Maccarrone, Dmitry B. Veprintsev, Marc Nazaré, Uwe Grether, Erick M. Carreira
Journal/Proc./Book: Journal of the American Chemical Society (142/40)
Year: 2020
Thematic Pillar: Metabolic and Cardiovascular Diseases

10. Anti-PD-1 Therapy Does Not Influence Hearing Ability in the Most
Sensitive Frequency Range, but Mitigates Outer Hair Cell Loss in the
Basal Cochlear Regio n

Judit Szepesy, Gabriella Miklós, János Farkas, Dániel Kucsera, Zoltán Giricz, Anita Gáborján, Gábor Polony, Ágnes Szirmai, László Tamás, László Köles, Zoltán V. Varga, Tibor Zelles
Year: 2020
Journal/Proc./Book: International Journal of Molecular Sciences (21/18)
Thematic Pillar: Metabolic and Cardiovascular Diseases

9. Chronic treatment with rofecoxib but not ischemic preconditioning of the myocardium ameliorates early intestinal damage following cardiac ischemia/reperfusion injury in rats

Szilvia B. László, Bernadette Lázár, Gábor B. Brenner, András Makkos, Mihály Balogh, Mahmoud Al-Khrasani, Barbara Hutka, Amir Mohammadzadeh, Ágnes Kemény, Terézia László, Bálint Scheich, Tamara Szabados, Éva Kenyeres, Zoltán Giricz, Péter Bencsik, Zoltán V. Varga, Julianna Novák, Zsuzsanna Helyes, Péter Ferdinandy, Klára Gyires, Zoltán S. Zádori
Journal/Proc./Book: Biochemical Pharmacology (178)
Year: 2020
Thematic Pillar: Metabolic and Cardiovascular Diseases

8. Cardiac miRNA Expression and their mRNA Targets in a Rat Model of Prediabetes

Éva Sághy, Imre Vörös, Bence Ágg, Bernadett Kiss, Gábor Koncsos, Zoltán V. Varga, Anikó Görbe, Zoltán Giricz, Rainer Schulz, Péter Ferdinandy
Journal/Proc./Book: International Journal of Molecular Sciences (21/6)
Year: 2020
Thematic Pillar: Metabolic and Cardiovascular Diseases

7. Simple binding of protein kinase A prior to phosphorylation allows CFTR anion channels to be opened by nucleotides

Csaba Mihályi, Iordan Iordanov, Beáta Töröcsik, László Csanády
Journal/Proc./Book: Proceedings of the National Academy of Sciences (117/35)
Year: 2020
Thematic Pillar: Metabolic and Cardiovascular Diseases

6. Limited Evolutionary Conservation of the Phenotypic Effects of Antibiotic Resistance Mutations

Gábor Apjok, Gábor Boross, Ákos Nyerges, Gergely Fekete, Viktória Lázár, Balázs Papp, Csaba Pál, Bálint Csörgő
Journal/Proc./Book: Molecular Biology and Evolution (36/8)
Year: 2019
Thematic Pillar: Metabolic and Cardiovascular Diseases

5. Exploring the fitness benefits of genome reduction in Escherichia coli by a selection-driven approach

Viktor Vernyik, Ildikó Karcagi, Edit Tímár, István Nagy, Ádám Györkei, Balázs Papp, Zsuzsanna Györfy, György Pósfai
Journal/Proc./Book: Scientific Reports (10/1)
Year: 2020
Thematic Pillar: Metabolic and Cardiovascular Diseases

4. Activity-based protein profiling of the human failing ischemic heart
reveals alterations in hydrolase activities involving the
endocannabinoid system

Annelot C.M. van Esbroeck, Zoltan V. Varga, Xinyu Di, Eva J. van Rooden, Viktória E. Tóth, Zsófia Onódi, Mariusz Kuśmierczyk, Przemyslaw Leszek, Péter Ferdinandy, Thomas Hankemeier, Mario van der Stelt, Pál Pacher
Journal/Proc./Book: Pharmacological Research (151)
Year: 2019
Thematic Pillar: Metabolic and Cardiovascular Diseases

3. Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion

Anett Dunai, Réka Spohn, Zoltán Farkas, Viktória Lázár, Ádám Györkei, Gábor Apjok, Gábor Boross, Balázs Szappanos, Gábor Grézal, Anikó Faragó, László Bodai, Balázs Papp, Csaba Pál

Journal/Proc./Book: eLife (-)
Year: 2019
Thematic Pillar: Metabolic and Cardiovascular Diseases

2. Unmatched level of molecular convergence among deeply divergent complex multicellular fungi

Zsolt Merényi, Arun N Prasanna, Zheng Wang, Károly Kovács, Botond Hegedüs, Balázs Bálint, Balázs Papp, Jeffrey P Townsend, László G Nagy

Journal/Proc./Book: Molecular Biology and Evolution (-)
Year: 2019
Thematic Pillar: Metabolic and Cardiovascular Diseases

1. Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action

Bálint Kintses, Pramod K. Jangir, Gergely Fekete, Mónika Számel, Orsolya Méhi, Réka Spohn, Lejla Daruka, Ana Martins, Ali Hosseinnia, Alla Gagarinova, Sunyoung Kim, Sadhna Phanse, Bálint Csörgő, Ádám Györkei, Eszter Ari, Viktória Lázár, István Nagy, Mohan Babu, Csaba Pál, Balázs Papp
Journal/Proc./Book: Nature Communications (10/1)
Year: 2019
Thematic Pillar: Immuno-inflammatory Diseases / Metabolic and Cardiovascular Diseases

Metabolic and Cardiovascular Diseases

31. Systematic transcriptomic and phenotypic characterization of human and murine cardiac myocyte cell lines and primary cardiomyocytes reveals serious limitations and low resemblances to adult cardiac phenotype. J Mol Cell Cardiol.

30. Molecular pathology of the R117H cystic fibrosis mutation is explained by loss of a hydrogen bond.

29. Somatostatin and Its Receptors in Myocardial Ischemia/Reperfusion Injury and Cardioprotection

28. SignaLink3: a multi-layered resource to uncover tissue-specific signaling networks

27. Molecular Network Approach Reveals Rictor as a Central Target of Cardiac ProtectomiRs

26. Degenerate but indispensable: how CFTR channel activity depends on the catalytically inactive ATP binding site?

25. The Effect of Molecular Weight on the Solubility Properties of Biocompatible Poly(ethylene succinate) Polyester

24. Delayed Contralateral Nephrectomy Halted Post-Ischemic Renal Fibrosis Progression and Inhibited the Ischemia-Induced Fibromir Upregulation in Mice

23. Evidence of a Myenteric Plexus Barrier and its Macrophage-Dependent Degradation during Murine Colitis: Implications in Enteric Neuroinflammation

22. Negative trade-off between neoantigen repertoire breadth and the specificity of HLA-I molecules shapes antitumor immunity

21. Bicarbonate Evokes Reciprocal Changes in Intracellular Cyclic di-GMP and Cyclic AMP Levels in Pseudomonas aeruginosa

20. Systematic review and network analysis of microRNAs involved in cardioprotection against myocardial ischemia/reperfusion injury and infarction: Involvement of redox signalling

19. AIM2-driven inflammasome activation in heart failure

18. Alcohol in Psoriasis—From Bench to Bedside

17. Two Decades of Evolution of Our Understanding of the Transient Receptor Potential Melastatin 2 (TRPM2) Cation Channel

16. Characterization of Neurons Expressing the Novel Analgesic Drug Target Somatostatin Receptor 4 in Mouse and Human Brains

15. Influence of cardiometabolic comorbidities on myocardial function,
infarction, and CARDIOPROTECTION: Role of cardiac redox signaling

14. PCSK9 in Myocardial Infarction and Cardioprotection: Importance of Lipid Metabolism and Inflammation

13. Suboptimal global transcriptional response increases the harmful effects of loss-of-function mutations

12. Characterization of Neurons Expressing the Novel Analgesic Drug Target Somatostatin Receptor 4 in Mouse and Human Brains

11. Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells

10. Anti-PD-1 Therapy Does Not Influence Hearing Ability in the Most
Sensitive Frequency Range, but Mitigates Outer Hair Cell Loss in the
Basal Cochlear Regio n

9. Chronic treatment with rofecoxib but not ischemic preconditioning of the myocardium ameliorates early intestinal damage following cardiac ischemia/reperfusion injury in rats

8. Cardiac miRNA Expression and their mRNA Targets in a Rat Model of Prediabetes

7. Simple binding of protein kinase A prior to phosphorylation allows CFTR anion channels to be opened by nucleotides

6. Limited Evolutionary Conservation of the Phenotypic Effects of Antibiotic Resistance Mutations

5. Exploring the fitness benefits of genome reduction in Escherichia coli by a selection-driven approach

4. Activity-based protein profiling of the human failing ischemic heart
reveals alterations in hydrolase activities involving the
endocannabinoid system

3. Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion

2. Unmatched level of molecular convergence among deeply divergent complex multicellular fungi

1. Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action

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About HCEMM

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Metabolic and Cardiovascular Diseases

31. Systematic transcriptomic and phenotypic characterization of human and murine cardiac myocyte cell lines and primary cardiomyocytes reveals serious limitations and low resemblances to adult cardiac phenotype. J Mol Cell Cardiol.

30. Molecular pathology of the R117H cystic fibrosis mutation is explained by loss of a hydrogen bond.

29. Somatostatin and Its Receptors in Myocardial Ischemia/Reperfusion Injury and Cardioprotection

28. SignaLink3: a multi-layered resource to uncover tissue-specific signaling networks

27. Molecular Network Approach Reveals Rictor as a Central Target of Cardiac ProtectomiRs

26. Degenerate but indispensable: how CFTR channel activity depends on the catalytically inactive ATP binding site?

6. Limited Evolutionary Conservation of the Phenotypic Effects of Antibiotic Resistance Mutations

4. Activity-based protein profiling of the human failing ischemic heartreveals alterations in hydrolase activities involving theendocannabinoid system

3. Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion

2. Unmatched level of molecular convergence among deeply divergent complex multicellular fungi

1. Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action

Consortium

About HCEMM

Internal Policies

Contact Info

4. Activity-based protein profiling of the human failing ischemic heart
reveals alterations in hydrolase activities involving the
endocannabinoid system