PERSONAL INFORMATION

Family name, First name: László, Csanády
Researcher unique identifier: O-5784-2017
Google Scholar:
ORCID: 0000-0002-6547-5889
URL for web site: https://semmelweis.hu/biokemia/research/csanady-group/

Education/Degrees:

1989-1995    Semmelweis University Medical School, Budapest: medicine, M.D. (1995)
1995-2000    The Rockefeller University, New York: biophysics/physiology, Ph.D. (2000)
2016               Hungarian Academy of Sciences: D.Sc. (2016)

Positions and Employment:

Semmelweis University, Department of Medical Biochemistry
2020-            Chair, Institute of Biochemistry and Molecular Biology

2018-            Professor

2009-2018    Associate Professor

2007-2009    Assistant Professor

2003-2007    Instructor

2000-2003    Postdoctoral fellow

Professional Memberships:

      Biophysical Society (member since 1997)

      Elife (member of board of reviewing editors since 2017)

Peer Review Work:

Journals: Journal of General Physiology, Journal of Physiology, British Journal of Pharmacology, Journal of Biological Chemistry, Proc Natl Acad Sci USA, Nat Commun, Elife

Funding agencies: Cystic Fibrosis Trust, Wellcome Trust, Hungarian Scientific Research Fund

Awards and Honors:

1992-95  Fellowship of the Hungarian Republic

1995       1st Prize, Student Research Conference (Semmelweis University)

1999       Gosau Young Investigator Award (FEBS Advanced Lecture Course)

2006       Gedeon Richter Research Career Award

2006       János Bolyai Research Fellowship (Hungarian Academy of Sciences)

2008       Tivadar Huzella Award (Semmelweis University)

2010       János Bolyai Research Fellowship (Hungarian Academy of Sciences)

2012       International Early Career Scientist Award (Howard Hughes Medical Institute)

2012       Merit Award (Semmelweis University)

2013       Habilitation (Semmelweis University)

2014       Merit Award (Semmelweis University)

2014       Distinguished Teacher Award (Semmelweis University)

2015       Paul Cranefield Award (Society of General Physiologists)

2016       Doctor of the Hungarian Academy of Sciences (Hungarian Academy of Sciences)

2016       Merit Award (Semmelweis University)

2017       Academy Award (Hungarian Academy of Sciences)

2021       Széchenyi Award

Ten most important publications:

1. Mihályi, C., Iordanov, I., Töröcsik, B., Csanády, L. 2020. Simple binding of protein kinase A, prior to phosphorylation, allows CFTR anion channels to be opened by nucleotides. Proc. Natl. Acad. Sci. USA. 117:21740-6.
2. Iordanov I, Tóth B, Szollosi A, Csanády L. 2019. Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates. Elife 8. pii: e44556.
3. Csanády L, Vergani P, Gadsby DC. 2019. Structure, gating, and regulation of the CFTR anion channel. Physiol Rev. 99:707-738.
4. Zhang Z, Tóth B, Szollosi A, Chen J, Csanády L. 2018. Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation. Elife 7. pii: e36409.
5. Sorum B, Töröcsik B, Csanády L. 2017. Asymmetry of movements in CFTR’s two ATP sites during pore opening serves their distinct functions. Elife 6. pii: e29013.
6. Liu F, Zhang Z, Csanády L, Gadbsy DC, Chen J. 2017. Molecular stucture of the human CFTR ion channel. Cell 169:85-95.
7. Mihályi, C, Torocsik, B, Csanády, L. 2016. Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerization. Elife 5. pii:e18164. doi:10.7554/eLife.18164., e18164. PMCID:PMC4956468
8. Iordanov I, Mihályi C, Tóth B, Csanády L. 2016. The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity. Elife 5. pii:e17600. doi:10.7554/eLife.17600., e17600. PMCID:PMC4974056
9. Sorum, B, Czege, D, Csanády, L. 2015. Timing of CFTR Pore Opening and Structure of Its Transition State. Cell 163, 724-733. PMID:26496611
10. Tóth, B., Iordanov, I., Csanády, L. 2014. Putative chanzyme activity of TRPM2 cation channel is unrelated to pore gating. Proc. Natl. Acad. Sci. USA. 111:16949-54. PMCID:PMC4250100
11. Tóth B, Csanády L. 2012. Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents. Proc. Natl. Acad. Sci. USA. 109:13440-5. PMCID:PMC3421201
12. Csanády, L., Vergani, P., Gadsby, D.C. 2010. Strict coupling between CFTR’s catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations. Proc. Natl. Acad. Sci. USA. 107:1241-1246. PMCID: PMC2824283
13. Gadsby, D.C., Vergani, P., Csanády, L. 2006. The ABC protein turned chloride channel whose failure causes cystic fibrosis. Nature 440:477-483. PMCID: PMC2720541

Ongoing research support:

2017-2022: Hungarian Academy of Sciences Momentum Award

2021-2023: Cystic Fibrosis Foundation Research Grant

2019-2024: Hungarian Center of Excellence for Molecular Medicine Resrach Group Leader Award

Completed research support:

2017-2019: Cystic Fibrosis Foundation Research Grant

2012-2017: Howard Hughes Medical Institute International Early Career Scientist Award

2015-2017: Cystic Fibrosis Foundation Research Grant

2012-2017: Hungarian Academy of Sciences Momentum Award

2010-2015: National Institutes of Health Research Grant (R01)

2007-2011: Wellcome Trust Project Grant

2007-2011: FIRCA Basic Biomedical (FIRCA-BB)