Precision Medicine

Precision Medicine

The biological complexity of major non-communicable diseases, such as cancer, metabolic-cardiovascular and immune-inflammatory disorders requires entirely new approaches like solutions related to systems medicine. Systems medicine, an emerging approach applied to biomedical and biological scientific research, is a true interdisciplinary field of study that focuses on both horizontal and vertical interactions within biological systems. This holistic approach is extremely well suited to cover complex biological and biomedical events in health and disease. For instance, the Human Genome Project is an example of applied systems thinking in biology, which has led to new, collaborative ways of working on problems in the field of genetics. One of the outreaching aims of systems biology is to model and discover emergent properties; typically those involving metabolic- or cell signaling networks, providing direct links to pharmacological discoveries. However, the concept of state-of-the-art precision medicine goes far beyond systems biology and medicine. Indeed, modern, personalized and ‘targeted’ medicine approaches require (among others) high-end bioinformatics, ‘big data handling’, and bioanalytics, as well as cutting-edge technologies of structure biology, molecular engineering, and nanomedicine. As these emerging fields of basic and applied science are identified as technological strengths of the founding institutions of the HCEMM, they perfectly complement and further support the thematic research activities.
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