Group Leader: Nikolett Wohner MD, PhD
Our research focuses on translational medicine in the field of thrombosis and hemostasis. Thrombi are complex structures that cannot be investigated in simplified systems, as red blood cells, leukocytes, platelets and molecules originating from these cells profoundly determine thrombus formation and
thrombolysis. In our studies we use in vitro, ex vivo and in vivo methods combined with advanced
microscopic technics to uncover the pathophysiology of hemostatic processes. We concentrate on the role of neutrophil extracellular traps, von Willebrand factor and the interaction thereof. Furthermore, we aim to shed light on the pathomechanism of bleeding or thrombotic complications in hematological diseases. Our results may thoroughly affect the development of new thrombolytic therapies and help to
identify new thrombotic markers.