HCEMM-SU Translational Dermatology Research Group

Group Leader

Kemény Lajos Vince, MD, PhD

Group Leader

PERSONAL INFORMATION

ORCID ID: 0000-0002-8233-1844

WORK EXPERIENCE

2022- Group Leader, HCEMM-SE Translational Dermatology Research Group, Department of Physiology, Semmelweis University

2020 – Dermatology Resident, Dept. Of Dermatology, Semmelweis University

2015 –2020 Postdoctoral Researcher in the lab of Dr. David Fisher, Massachusettes General Hospital, Harvard Medical School, Boston, MA

2013 – 2014 Dermatology Resident, Dept. Of Dermatology, University of Szeged

2009-2013 Student Researcher, Dept. Of Internal Medicine, University of Szeged

2013 Elective student, Department of Clinical Neurology, University of Oxford, UK 2013 (1 mo)

2012 Student Researcher in the lab of Dr. Allen Verkman, Department of Nephrology, University of California, San Francisco 2012 (2 months)

2011 Student Researcher in the lab of Dr. David Yule, Department of Phsysiology, University of Rochester, NY, USA 2011 (3 months)

2011 Student Lecturer, Dept. Of Pharmacology, University of Szeged

2008-2009 Student Researcher, Dept. Of Physiology, University of Szeged

EDUCATION

2014-2021 Postdoctoral training

Harvard Medical School and Massachusetts General Hospital

Supervisor: Dr. David Fisher

2014 PhD, University of Szeged

Diploma: summa cum laude

2007 – 2013 M.D., University of Szeged

Diploma: summa cum laude

2003 – 2007 Ságvári Endre High School, Szeged

AWARDS AND SCHOLARSHIPS

2021 Junior Prima Award

2021-2024 János Bolyai Research Scholarship of the Hungarian Academy of Sciences

2015 Eötvös Loránd Scholarship (6 mo)

2012-2013 Scholarship of the Hungarian Republic

2010-2013 Outstanding Student Fellowship, University of Szeged

2013 Eötvös Loránd Student Fellowship

2012 Rosztóczy Scholarship (3 mo)

2013 Special Merit, Országos Tudományos Diákköri Konferencia, Szeged

2012 Third Price, SZTE ÁOK, Student Conference, Szeged

2012 Third Price, SZTE ÁOK, Student Conference, Szeged

2011 Dean‘s Award, SZTE ÁOK, Student Conference, Szeged

2011 Third Price, SZTE ÁOK, Student Conference, Szeged

SUPERVISION OF GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS

2022 – 3 PhD Students, Semmelweis University

2022 – 4 MD Student, Semmelweis University

2021 – 1 MD Student, Semmelweis University, student co-authored a paper

2016-2017 1 Master Student (co-mentored with David Fisher at MGH, thesis submitted to Technische Universität München). Student co-authored a paper

2014-2020 Project supervisor, Cutaneous Biology Research Center, 1 MD student, 1 college student, 2 High School students. All students co-authored a paper

MEMBERSHIPS OF SCIENTIFIC SOCIETIES

2021 – Secretary, USA-Hungary relations, Hungarian Society for Dermatology Research

2018 – Member, Hungarian Society for Dermatology Research

2018 – Member, European Society for Dermatology Research

2009-2013 Member, European Pancreatic Club

2009–2013 Member, Hungarian Society for Gastroenterology Research

MAJOR COLLABORATIONS

– David E. Fisher, melanocyte and melanoma biology, Cutaneous Biology Research Center, Harvard Medical School, Boston, MA

– György Marko-Varga, proteomics of melanoma, Department of Biomedical Engineering, Lund University

– Zsuzsanna Kurgyis, UV-induced changes in epithelia, Department of Dermatology, Technische Universität München

-Aniruddha Deshpande, Epigenetics and CRISPR-cas9 screens, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California

METRICS (2022 July)

Google Scholar: H-index: 10, i10 index 10, citations 715

Research Gate H-index: 8, citations 529

Number of publications (2022 July)

Number of D1 publications: 12

Number of Q1 publications: 4

Number of first and last authored publications

Number of D1 first and last authored publications: 4

Number of Q1 first and last authored publications: 3

Original Publications (2022 July)

1. Gil, J., Rezeli, M., Lutz, E. G., Kim, Y., Sugihara, Y., Malm, J., Semenov, Y. R., Yu, K. H., Nguyen, N., Wan, G., Kemény, L. V., Kárpáti, S., Németh, I. B., & Marko-Varga, G. (2021). An Observational Study on the Molecular Profiling of Primary Melanomas Reveals a Progression Dependence on Mitochondrial Activation. Cancers, 13(23), 6066.

2. Kurgyis, Z., Vornholz, L., Pechloff, K., Kemény, L. V., Wartewig, T., Muschaweckh, A., Joshi, A., Kranen, K., Hartjes, L., Möckel, S., Steiger, K., Hameister, E., Volz, T., Mellett, M., French, L. E., Biedermann, T., Korn, T., & Ruland, J. (2021). Keratinocyte-intrinsic BCL10/MALT1 activity initiates and amplifies psoriasiform skin inflammation. Science immunology, 6(65), eabi4425.

3. Allouche J, Rachmin I, Adhikari K, Pardo LM, Lee JH, McConnell AM, Kato S, Fan S, Kawakami A, Suita Y, Wakamatsu K, Igras V, Zhang J, Navarro PP, Lugo CM, Noonan HR, Christie KA, Itin K, Mujahid N, Lo JA, Won CH, Evans CL, Weng QY, Wang H, Osseiran S, Lovas A, Németh I, Cozzio A, Navarini AA, Hsiao JJ, Nguyen N, Kemény LV, Iliopoulos O, Berking C, Ruzicka T, Gonzalez-José R, Bortolini MC, Canizales-Quinteros S, Acuna-Alonso V, Gallo C, Poletti G, Bedoya G, Rothhammer F, Ito S, Schiaffino MV, Chao LH, Kleinstiver BP, Tishkoff S, Zon LI, Nijsten T, Ruiz-Linares A, Fisher DE, Roider E. NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism. Cell. 2021 Jun 29:S0092-8674(21)00757-1.

4. LV Kemény*, KC. Robinson*, Yik Weng Yew, Yi Chun Lai, AL Hermann, PD Rivera, T Beyer, Yong-Hwee E. Loh, DM Walker, JA Lo, AAJ van der Sande, W Sarnie, JJ Hsiao, MY Su, S Kato, SD. Bilbo, V Chopra, MP Salomon, DSB Hoon, MM Asgari, EJ Nestler, DE Fisher. Vitamin D deficiency drives UV/endorphin and opiate addiction. Sci Adv., 2021, Jun 11;7(24):eabe4577.

5. KC Robinson*, LV Kemeny*, GL Fell, J Allouche, AL Hermann, A Yekkirala, JJ Hsiao, MY Su, G Kozak, Y Takeuchi, A Berenyi, J Mao, CJ Woolf, David E. Fisher. Reduced melanocortin signaling alters nociceptive thresholds associated with red hair. Sci Adv. 2021 Apr 2; 7(14):eabd1310.

6. JA Lo, M Kawakubo, VR Juneja, MY Su, MW LaFleur, LV Kemeny, M Rashid, KE Pauken, DT Frederick, QY Weng, M Pereira, Y Xu, AAJ van der Sande, W Silkworth, EM Roider, EP Browne, DJ Lieb, B Wang, LA Garraway, CJ Wu, KT Flaherty, CE Brinckerhoff, DW Mullins, DJ Adams, N Hacohen, GM Boland, GJ Freeman, AH Sharpe, D Manstein, DE Fisher. Rescuing response to immune checkpoint blockade in neoantigen-deficient cancers. Sci Transl Med. 2021 Feb 17;13(581):eabd8636.

7. S Kato, Q Weng, M Insco, K Chen, S Muralidhar, J Poźniak, J Diaz, Y Drier, E van Rooijen, LV Kemeny, Y Zhan, Y Feng, W Silkworth, C Powell, B Liau, Y Xiong, J Jin, J Newton-Bishop, L Zon, B Bernstein, DE Fisher. Novel gain-of-function genetic alterations of G9a drive oncogenesis. Cancer Discov. 2020 Jul;10(7):980-997.

8. Venglovecz V, Pallagi P, Kemény LV, Balázs A, Balla Z, Becskeházi E, Gál E, Tóth E, Zvara Á, Puskás LG, Borka K, Sendler M, Lerch MM, Mayerle J, Kühn JP, Rakonczay Z Jr, Hegyi P. The Importance of Aquaporin 1 in Pancreatitis and Its Relation to the CFTR Cl(-) Channel. Front Physiol. 2018 Jul 12;9:854.

9. Kemeny LV, Fisher DE. Targeting the (Un)differentiated State of Cancer. Cancer Cell. 2018 May 14;33(5):793-795. doi: 10.1016/j.ccell.2018.04.007.

10. Mujahid N, Liang Y, Murakami R, Choi HG, Dobry AS, Wang J, Suita Y, Weng QY, Allouche J, Kemeny LV, Hermann AL, Roider EM, Gray NS, Fisher DE. A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin. Cell Rep. 2017 Jun 13;19(11):2177-2184.

11. Kurgyis Z*, Kemény LV*, Buknicz T, Groma G, Oláh J, Jakab Á, Polyánka H, Zänker K, Dittmar T, Kemény L, Németh IB. Melanoma-Derived BRAF(V600E) Mutation in Peritumoral Stromal Cells: Implications for in Vivo Cell Fusion. Int J Mol Sci. 2016 Jun 21;17(6).

12. Kemény LV*, Kurgyis Z, Buknicz T, Groma G, Jakab Á, Zänker K, Dittmar T, Kemény L, Németh IB. Melanoma Cells Can Adopt the Phenotype of Stromal Fibroblasts and Macrophages by Spontaneous Cell Fusion in Vitro. Int J Mol Sci. 2016 Jun 2;17(6).

13. Tateishi K, Wakimoto H, Iafrate AJ, Tanaka S, Loebel F, Lelic N, Wiederschain D, Bedel O, Deng G, Zhang B, He T, Shi X, Gerszten RE, Zhang Y, Yeh JJ, Curry WT, Zhao D, Sundaram S, Nigim F, Koerner MVA, Ho Q, Fisher DE, Roider EM, Kemeny LV, Samuels Y, Flaherty KT, Batchelor TT, Chi AS, Cahill DP. Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion. Cancer Cell. 2015 Dec 14;28(6):773-784.

14. Maléth J, Balázs A, Pallagi P, Balla Z, Kui B, Katona M, Judák L, Németh I, Kemény LV, Rakonczay Z Jr, Venglovecz V, Földesi I, Pető Z, Somorácz Á, Borka K, Perdomo D, Lukacs GL, Gray MA, Monterisi S, Zaccolo M, Sendler M, Mayerle J, Kühn JP, Lerch MM, Sahin-Tóth M, Hegyi P. Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis. Gastroenterology. 2015 Feb;148(2):427-39.e16.

15. Kemény LV*, Schnúr A*, Czepán M, Rakonczay Z Jr, Gál E, Lonovics J, Lázár G, Simonka Z, Venglovecz V, Maléth J, Judák L, Németh IB, Szabó K, Almássy J, Virág L, Geisz A, Tiszlavicz L, Yule DI, Wittmann T, Varró A, Hegyi P. Na+/Ca2+ exchangers regulate the migration and proliferation of human gastric myofibroblasts. Am J Physiol Gastrointest Liver Physiol. 2013 Oct 15;305(8):G552-63.

16. Kemény LV, Hegyi P, Rakonczay Z Jr, Borka K, Korompay A, Gray MA, Argent BE, Venglovecz V. Substance P inhibits pancreatic ductal bicarbonate secretion via neurokinin receptors 2 and 3 in the guinea pig exocrine pancreas. Pancreas. 2011 Jul;40(5):793-5.

Other publications

1: Kemeny LV, Fisher DE. Hormones and Hormone Precursors of the Skin. Hormonal Signaling in Biology and Medicine (Book Chapter in Hormonal Signaling in Biology and Medicine, 1st. Edition 2020)

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