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Ákos Menyhárt

Ákos Menyhárt

PUBLICATIONSCONTACT

Selected publications

  1. Szabó, Í., Varga, V.É., Dvorácskó, S., Farkas, A.E., Körmöczi, T., Berkecz, R., Kecskés, S., Menyhárt, Á., Frank, R., Hantosi, D., Cozzi, N.V., Frecska, E., Tömböly, C., Krizbai, I.A., Bari, F., Farkas, E. (2021) N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain. Neuropharmacology. 192, 108612.
  2. Frank, R., Bari, F., Menyhárt, Á., Farkas, E. (2021) Comparative analysis of spreading depolarizations in brain slices exposed to osmotic or metabolic stress. BMC Neurosci. 22(1), 33.
  3. Tóth, R., Farkas, A.E., Krizbai, I.A., Makra, P., Bari, F., Farkas, E., Menyhárt, Á. (2021) Astrocyte Ca2+ Waves and Subsequent Non-Synchronized Ca2+ Oscillations Coincide with Arteriole Diameter Changes in Response to Spreading Depolarization. Int. J. Mol. Sci. 22(7), 3442.
  4. M. Tóth, O., Menyhárt, Á., Frank, R., Hantosi, D., Farkas, E., Bari, F. (2020) Tissue acidosis associated with ischemic stroke to guide neuroprotective drug delivery. Biology (Basel). 9(12), 460.
  5. Varga, D.P, Szabó, Í., Varga, V.É., Menhyárt, Á., M. Tóth, O., Kozma, M., Bálint, A.R., Krizbai, I.A., Bari, F., Farkas, E. (2020) The antagonism of prostaglandin FP receptors inhibits the evolution of spreading depolarization in an experimental model of global forebrain ischemia. Neurobiol. Dis. 137, 104780.
  6. Varga, D.P., Menyhárt, Á., Pósfai, B., Császár, E., Lénárt, N., Cserép, C., Orsolits, B., Martinecz, B., Szlepák, T., Bari, F., Farkas, E., Dénes Á. (2020) Microglia alter the threshold of spreading depolarization and related potassium uptake in the mouse brain. J. Cereb. Blood Flow Metab. 27, 271678X19900097.
  7. M. Tóth, O., Menyhárt, Á., Varga, V.É., Hantosi, D., Ivánkovits-Kiss, O., Varga, D.P., Szabó, Í., Janovák, L., Dékány, I., Farkas, E., Bari, F. (2020) Chitosan nanoparticles release nimodipine in response to tissue acidosis to attenuate spreading depolarization evoked during forebrain ischemia. Neuropharmacology. 162, 107850.
  8. Bálint, A.R., Puskás, T, Menyhárt, Á., Kozák, Á., Szenti, I., Kónya, Z., Marek, T., Bari, F., Farkas, E. (2019) Aging impairs cerebrovascular reactivity at preserved resting cerebral arteriolar tone and vascular density in the laboratory rat. Front. Aging Neurosci. 11, 301.
  9. Szabó, Í., M.Tóth, O., Török, Z., Varga, D.P., Menyhárt, Á., Frank, R., Hantosi, D., Hunya, Á., Bari, F., Horváth, I., Vigh, L., Farkas, E. (2019) The impact of dihydropyridine derivatives on the cerebral blood flow response to somatosensory stimulation and spreading depolarization. Br. J. Pharmacol. 176(9), 1222-1234.
  10. Hertelendy, P., Varga, D.P., Menyhárt, Á., Bari, F., Farkas, E. (2019) Susceptibility of the cerebral cortex to spreading depolarization in neurological disease states: The impact of aging. Neurochem. Int. 127, 125-136.
  11. Makra, P., Menyhárt, Á., Bari, F., Farkas, E. (2018) Spectral and multifractal signature of cortical spreading depolarisation in aged rats. Front. Physiol. 9, 1512.
  12. Menyhárt, Á., Farkas, A.E., Varga, D.P., Frank, R., Tóth, R., Bálint, A.R., Makra, P., Dreier, J.P., Bari, F., Krizbai, I.A., Farkas, E. (2018) Large-conductance Ca2+-activated potassium channels are potently involved in the inverse neurovascular response to spreading depolarization. Neurobiol. Dis. 119, 41‑52.
  13. Menyhárt, Á., Zölei-Szénási, D., Puskás, T., Makra, P., Bari, F., Farkas, E. (2017) Age or ischemia uncouples the blood flow response, tissue acidosis, and the direct current potential signature of spreading depolarization in the rat brain. Am. J. Physiol. Heart Circ. Physiol. 313(2), H328-H337.
  14. Editorial on this paper: Marinesco, S., Ungvári, Z., Galvan, V. (2017) Age-related impairment of metabo-vascular coupling during cortical spreading depolarization. Am. J. Physiol. Heart Circ. Physiol. 313(6), H1209-H1212.
  15. Varga, D.P., Menyhárt, Á., Puskás, T., Bari, F., Farkas, E., Kis, Z., Vécsei, L., Toldi, J., Gellért, L. (2017) Systemic administration of L-kynurenine sulfate induces cerebral hypoperfusion transients in adult C57Bl/6 mice. Microvasc. Res., 114, 19-25.
  16. Menyhárt, Á., Zölei-Szénási, D., Puskás, T., Makra, P., M.Tóth, O., Szepes, B.É., Tóth, R., Ivánkovits-Kiss, O., Obrenovitch, T.P., Bari, F., Farkas, E. (2017) Spreading depolarization remarkably exacerbates ischemia-induced tissue acidosis in the young and aged rat brain. Sci Rep. 7(1), 1154.
  17. Hertelendy P., Menyhárt Á., Makra P., Süle Z., Kiss T., Tóth G., Ivánkovits-Kiss, O., Bari, F., Farkas., E. (2017) Advancing age and ischemia elevate the electric threshold to elicit spreading depolarization in the cerebral cortex of young adult rats. J. Cereb. Blood Flow Metab. 37(5), 1763-1775.
  18. Varga, D.P., Puskás, T., Menyhárt, Á., Hertelendy, P., Zölei-Szénási, D., Tóth, R., Ivánkovits-Kiss, O., Bari, F., Farkas, E. (2016) Contribution of prostanoid signaling to the evolution of spreading depolarization and the associated cerebral blood flow response. Sci Rep. 6:31402. doi: 10.1038/srep31402.
  19. Menyhárt, Á., Makra, P., Szepes, B.É., M. Tóth, O., Hertelendy, P., Bari, F., Farkas, E. (2015) High incidence of adverse cerebral blood flow responses to spreading depolarization in the aged ischemic rat brain. Neurobiol. Aging, 36(12), 3269-77.
  20. Toth, P., Tarantini, S., Ashpole, N.M., Tucsek, Z., Milne, G.L., Valcarcel-Ares, N.M., Menyhart, A., Farkas, E., Sonntag, W.E., Csiszar, A., Ungvari, Z. (2015) IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging. Aging Cell, 14(6), 1034-44.
  21. Tarantini, S., Hertelendy, P., Tucsek, Z., Valcarcel-Ares, M.N., Smith, N., Menyhart, Á., Farkas, E., Hodges, E., Towner, R., Deak, F., Sonntag, W.E., Csiszar, A., Ungvari, Z., Tóth, P. (2015) Pharmacologically-induced neurovascular un-coupling is associated with cognitive impairment in mice. J. Cereb. Blood Flow Metab., 35(11), 1871-81.
  22. Oláh, G., Herédi, J., Menyhárt, A., Czinege, Z., Nagy, D., Fuzik. J., Kocsis, K., Knapp, L., Krucsó, E., Gellért, L., Kis, Z., Farkas, T., Fülöp, F., Párdutz, A., Tajti, J., Vécsei, L., Toldi, J. (2013) Unexpected effects of peripherally administered kynurenic acid on cortical spreading depression and related blood-brain barrier permeability. Drug Des. Devel. Ther. 7, 981-7.
  23. Gellért, L., Knapp, L., Németh, K., Herédi, J., Varga, D., Oláh, G., Kocsis, K., Menyhárt, A., Kis, Z., Farkas, T., Vécsei, L., Toldim J. (2013) Post-ischemic treatment with L-kynurenine sulfate exacerbates neuronal damage after transient middle cerebral artery occlusion. Neuroscience. 247, 95-101.
Pub

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 739593. HCEMM supported by EU Programme: H2020-EU.4.a. – Teaming of excellent research institutions and low performing RDI regions. Project starting date was 1 April 2017.

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