HCEMM-SU Cardiovascular Comorbidities Research Group

Group Leader

Nazha Hamdani, Ph.D.

Group Leader

PERSONAL

Title(s), initial(s), first name, surname: Nazha Hamdani, Ph.D.

EDUCATION

DOCTORATE DEGREE (Ph.D.)

University/College of Higher Education: Cardiovascular Research (ICAR-VU), VU University Medical Center Amsterdam, The Netherlands.

Master of Science degree (‘doctoral’)

University/College of Higher Education: Pharmaceutical Sciences, Free University, Amsterdam, The Netherlands. August 31, 2006

Study/main subject: Pharmaceutical Sciences, Pharmacochemistry/Molecular Toxicology and Molecular Pharmacology

WORK EXPERIENCE SINCE GRADUATING AND FELLOWSHIPS

2020 Head of Molecular and Experimental Cardiology, Division Cardiology, St-Joseph Hospital, Ruhr University Bochum, Germany.

2020 Group Leader HCEMM-SU Cardiovascular Comorbidities Research Group; Semmelweis University Department of Pharmacology and Pharmacotherapy

2019 – Deputy of Nucleus of the Working Group of Myokardiale Funktion und Energetik – AG13 of German Cardiac Society.

2016– Deputy of Nucleus of the Working Group of Myocardial Function of the ESC and the representative of the Working Group

2017–2020 Independent Group Leader; Institute of Physiology, System Physiology, Ruhr University, Bochum, Germany.

2016–2017 Independent Group Leader; Institute of Physiology, Cardiovascular Physiology, Ruhr University, Bochum, Germany.

2011-2015 Associate Researcher; Institute of Physiology, Cardiovascular Physiology, Ruhr University, Bochum, Germany.

2011-2015 Assistant Professor; Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, Amsterdam, The Netherlands.

Mar 2013 Guest Researcher, Department of Cardiovascular Sciences, Laboratory of Hypertensive Disease, Pamplona, Spain.

Nov 2011 Guest Researcher, Department of Physiology and Cardiothoracic Surgery, University of Porto, Portugal.

Sep-Oct 2008 Faculty of Medicine, National Heart & Lung Institute division of Imperial College London, United Kingdom.

2005- 2009 PhD student; Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, Amsterdam, The Netherlands.

UNIVERSITY TRAINING

Aug 2006 MSc degree; Pharmaceutical Sciences, Free University, Amsterdam, The Netherlands.

Aug 2005 Internship: Physiology, Laboratory for Physiology, Institute for Cardiovascular

2003-2004 Internship: Molecular Toxicology, Free University, Amsterdam, The  Netherlands.

Journalistic study (science journalist), Free University, Amsterdam, The Netherlands.

2003-2002 Post-graduate teacher training: Lectures studies to Biology and Chemistry studies, Free University, Amsterdam, The Netherlands.

Internship: Cell Biology & Biomedical Chemistry, Free University, Amsterdam, The Netherlands.

2001 – 2002 Internship: Molecular Toxicology, Free University, Amsterdam, The Netherlands.

2000 – 2001 Internship: Medicinal Pharmacology, Free University, Amsterdam, The Netherlands.

2001-2005 Master of Science (MSc) study; Pharmaceutical Sciences, Free University Amsterdam, The Netherlands. Master specialisations: Pharmacochemistry

Aug 2000 Graduation Propaedeutic exam Pharmacochemistry & Chemistry. Free University, Amsterdam, The Netherlands.

1998-2000 Propaedeutic degree Pharmacochemistry & Chemistry. Free University, Amsterdam, The Netherlands.

1994-1998 Medicine study; Free University, Brussels, Belgium.

1994- 1998 Economy and Management study, High school of Economy and Management Organization, Brussels, Belgium

SUPERVISION OF GRADUATE STUDENTS

2013 – to date 8 PhD students (finished) and 10 PhD students (ongoing/currently)/ 6 Postdocs (currently)/ 4 MD students/ approx. 25 Master/Bachelor Students. Extra open positions for one post-doc and two PhD students from Jan 2022 in my lab.

Medical Faculty, Ruhr University Bochum, Institute of Physiology, Cardiovascular Physiology, Germany.

Medical Faculty, Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, Amsterdam, The Netherlands

PH.D. THESIS COMPLETED UNDER MY SUPERVISION

Dr. Viola Corinne Roos (2014). Titin-Degradationsprodukte als potentielle Biomarker für Herzerkrankungen.

Dr. Constantijn Franssen (2017). Heart Failure with Preserved Ejection Fraction: The MEDIA Message.

Dr. Sophie Chen (2017). Heart Failure with Preserved Ejection Fraction from understanding the pathophysiology to treatment options based on sub-staging.

Dr. Martin Jan Breitkreuz (2017). Characterisierung des Redoxzustandes von Titin und Bedeutung der Titinoxidation für die Eigenschaften entfalteter Titindomäanen.

Melissa Herwig Msc (Nov 2020). Impact of cGMP-PKG Pathway Modulation on Titin Phosphorylation and Titin-Based Myocardial Passive Stiffness.

Detmar Kolijn Msc (Oct 2020). Potential targets of Heart Failure with preserved Ejection Fraction.

Roua Hassoun (Defense will be in Nov 2021). Mechanisms, Molecular, Cellular, and Clinical Aspects of Genetic Sarcomeric Mutations in Human Cardiomyopathies.

Heidi Budde (Defense will be in Nov 2021) Unraveling the Role of Inflammation and Oxidative Stress in Cardiovascular diseases development.

TEACHING ACTIVITIES

2005 – Physiology, Medical Faculty, Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, Amsterdam, The Netherlands.

2017– Institute of Physiology, Ruhr University, Bochum, Germany.

2011-2020 Invited lecturer at international Research institutions of cardiovascular within Europe:

– Medical Faculty, University of Porto, Portugal.

– Medical Faculty, Pamplona, Spain.

– National Institute of Cardiovascular Research (CNIC), Madrid, Spain.

– Department of Cardiology, Debrecen, Hungary.

– Experimental Cardiology Klinik für Kardiologie und Angiologie, Hannover, Germany

– Department of Molecular Cardiology, Heidelberg, Germany

– Department of Cardiology, Berlin, Germany

– Department of Cardiology Antwerp University Hospital (UZA) University of Antwerp (UA)

– Department of Cardiology, Regensburg, Germany

– Experimental Cardiology, Heidelberg, Germany

INTERNATIONAL ACTIVITIES

Invited Lectures/oral presentations

2020 Seminar at the Department of Cardiology, Berlin, Germany

2020 Frontiers in CardioVascular Biomedicine 2020 Congress (FCVB) from ESC, Budapest, Hungary

2020 Semmelweis University Department of Pharmacology and Pharmacotherapy, Budapest, Hungary

2019 Semmelweis Symposium, Budapest, Hungary

2019 Annual meeting of the Heart Failure Association of the European Society of Cardiology, Athens, Greece

2019 HFA Winter Meeting on Translational Heart Failure Research, Switzerland, Les Diableretes

2019 European Society of Cardiology meeting

2018 Basic Science meeting German Cardiac Society

2018 The 35th meeting of the International Society of Heart Research, Amsterdam, The Netherlands

2018 ESC Heart Failure meeting, Vienna, Austria

2018 Seminar University Hospital Regensburg, Germany

2018 Cardiovascular Research Days, Debrecen, Hungry

2017 Department of Cardiology Antwerp University Hospital (UZA) University of Antwerp (UA)

2017 Department of Cardiology, Berlin, Germany

2017 The European Society for Muscle Research Conference, Postdam, Germany

2017 Deutsche Gesellschaft für Kardiologie, Mannheim

2017 96th Annual Meeting of the German Physiology meeting, Greifswald, Germany

2017 The Biophysical Society 58th Annual Meeting in New Orleans

2017 Cellular and Molecular Medicine, Physiology, and Biomedical Engineering, Molecular Cardiovascular Research, University of Arizona, US

2017 Seminar at the Department of Cardiology and Angiology of the Hannover School of Medicine, Hannover, Germany

2017 HFA Winter Meeting on Translational Heart Failure Research, Switzerland, Les Diablerets

2016 6th World Congress of Oxidative Stress, Calcium Signalling & TRP Channels, Turkey

2016 Seminar at the Department of Molecular Cardiology, Heidelberg, Germany

2016 World Congress of International Society for Heart Research, Buenos Aires, Argentina

2016 Deutsche Gesellschaft für Kardiologie

2016 The Biophysical Society 57th Annual Meeting in Los Angles

2016 The 1st Cardiopulmonary Research Dialogue in Berlin, Germany

2016 Department of Pharmacology and Toxicology, Technical University Dresden, Germany

2015 International Society for Heart Research, Bordeaux, France

2015 The Biophysical Society 57th Annual Meeting in Baltimore

2015 Deutsche Gesellschaft für Kardiologie, Mannheim

2014 The European Society for Muscle Research Conference, Salzburg, Austria

2014 Seminar at the Department of Cardiology, Berlin, Germany

2014 Annual meeting of the Heart Failure Association of the European Society of Cardiology, Athens, Greece

2014 Basic Science Meeting of the DGK in Düsseldorf, Germany

2014 Deutsche Gesellschaft für Kardiologie, Mannheim

2014 German Physiological Society Annual Meeting, Mainz, Germany

2013 Internatl. Conference Myofibrillar Z-disk Structure and Dynamics, Hamburg, Germany

2011-2015 Annual Meeting of MEDIA-FP7, Amsterdam, The Netherlands

2013 Heart failure ESC meeting, Lisbon, Portugal

2013 Deutsche Gesellschaft für Kardiologie, Mannheim

2013 The Biophysical Society 57th Annual Meeting in Philadelphia, USA

2013 Seminar at the Department of Cardiology, Debrecen, Hungary

2013 Seminar at the Department of Cardiovascular Sciences, Laboratory of Hypertensive Disease, Pamplona 2013 German Physiological Society Annual Meeting, Heidelberg, Germany

2013 Dutch-German Joint Meeting of the Molecular Cardiology Groups, Heidelberg, Germany

2012 American Heart Association Meeting, Los Angles, USA

2012 The Biophysical Society 56th Annual Meeting in San Diego, USA

2012 German Cardiology Fall Meeting, Hamburg, Germany

2012 German Physiological Society Annual Meeting, Dresden, Germany

2011 International Society for Heart Research, Haifa, Israel

2011 The European Society for Muscle Research Conference, Berlin, Germany

2011 American Heart Association Meeting, Orlando, USA

2011 Seminar at the Department of Physiology and Cardiothoracic Surgery, University of Porto, Portugal

2010 The Joint Meeting of the Scandinavian and German Physiological Societies

2010 American Heart Association Meeting, Chicago, USA

2009 Seminar at the Department of Physiology, University of Arizona, Tucson, USA

2008 American Heart Association Meeting, New Orleans, USA

2007 American Heart Association Meeting, Orlando, USA

CONGRESSES

2011-2019 Heart Failure meeting European Society of Cardiology

2012-2018 The Biophysical Society Annual Meeting

2010-2019 German Cardiology Society Spring Meeting

2010- 2020 Heart Failure Winter Research Meetings

2010-2017 German Physiological Society Meetings

2011-2018 International Society for Heart Research Meeting

2010- 2019 European Society for Muscle Research Conferences

2009- 2020 European Society of Cardiology Annual congresses

2006-2017 American Heart Association Scientific Sessions

2006 European Physiological Society Meeting

ORGANIZATION OF SCIENTIFIC MEETINGS

2017 European Society for Muscle Research Conferences, Potsdam, 09/2017

2017 Symposium “The metabolic road to understanding Heart Failure with preserved Ejection Eraction”,

Amsterdam, 02/2017

2016- Session of the European Society of Cardiology (ESC) meeting

2016- Session of Heart Failure Association ESC meeting

2011-now Co-chair international meetings: European Society of Cardiology, International Society of Heart Research, Annual meeting of The Biophysical Society, European Society for Muscle Research, World Congress of Oxidative Stress, and Diastolic heart failure meeting / Conference on Diastolic heart failure meeting/ >150 participants / Amsterdam and Leiden.

INSTITUTIONAL RESPONSIBILITIES

2010 – Organizer of the Internal Seminar series, inviting national speakers from all Germany to give seminars. 2 to 3 speakers a month. Many Institutions/ Germany.

HONORS AND AWARDS

2020 – 1st price presentation in FORUM science day RUB (The impact of oxidative stress on aggregation and function of skeletal and cardiac muscle proteins).

2019 – Young Investigator award from Melissa Herwig (former PhD student in my group, post-doc in my group now) From Heart Failure association (Phosphorylation and oxidation of CaMKII modulate diastolic function).

2018 – 1st price poster presentation from Melissa Herwig (former PhD student in my group, post-doc in my group now) in German Cardiology Meeting (CaMKII interaction with PKG).

– 1st price poster presentation from Maria Lodi (former group member) in FORUM science day Bochum (Distinct signaling pathways in RV vs. LV from HFpEF patients).

2017: 2nd price poster presentation from Melissa Herwig (former PhD student in my group, post-doc in my group now) in German Cardiology Meeting (Cardiac stiffness modulation by cGMP).

2016 – 1st price presentation science day at RUB (Oxidation of proteins in Heart Failure)

2013 – Franz-Maximilian-Groedel-Forschungspreis

– Poster presentation price, ISHR meeting, USA

2012 – Award, Early Career Researchers of Ruhr University Bochum.

– Award, Science and Technology Foundation.

– Two oral presentation price, Diastolic Heart Failure Meeting

– Poster price, German Cardiology Society Spring Meeting

2011 – Publications price, the Netherlands Organization for scientific research.

– Teacher Prize, best teacher of the year

2010 – Hamburger award, (The best PhD thesis of 2009 from The Dutch Society of Physiology)

– Grant, V Coeverden Adriani foundation award (For postdoctoral fellowship abroad) – Dutch Cardiovascular award (The best PhD thesis of 2009 in The Netherlands)

– Travel grant, American Heart Association

– Pfizer award and Pfizer travel grant

– Teacher Prize, best teacher of the year

2009 – Award, European Society of Cardiology ((2 years postdoctoral fellowship abroad))

2006 – Oral presentation price, Institute for Cardiovascular Research VUMC and Leiden Vascular Medicine LUMC

(ICaR-VU & LVM) scientific day

2001 – Poster presentation price, symposium for bachelor students, VU University, Pharmaceutical sciences

MEMBERSHIP IN SCIENTIFIC SOCIETIES

American Heart Association

European Society for Muscle Research meeting

European Society of Cardiology

Biophysical Society

German Physiological Society

German Society of Cardiology

International Society of Heart Research

Activities on knowledge management (translation of results for the public, participation of patients in the research, etc.): Co-author of several “position papers” of the ESC and ESC CardioTalk. Live interviews for radio stations (e.g., Dutch science, 2015), Newspapers 2013-2017, Science journals (e.g., Circulation, 2011; Nature, 2015), and Knowledge distribution publications (e.g., International Innovation, 2015-2021). Regular press releases by Cardiovascular Physiology, Ruhr University, Bochum, Germany (RUB) and Free University Medical Center Amsterdam The Netherlands (VUmc).

Reviewer activities for: Reviewer for 20 different journals Nature Medicine, Circulation, Circulation Research, Circulation Heart Failure, Journal of Physiology, Cardiovascular Research, Journal of Molecular Cell Cardiology, European Heart Journal,European Journal of Heart Failure, Journal of Cardiovascular Pharmacology, Biochemistry Research International, Basic Research in Cardiology, Pflügers Archiv European Journal of Physiology, American Journal of Physiology – Heart and Circulatory Physiology, Journal of Physiology Cellular Physiology and Biochemistry.

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