Szilvia Krizsan MD

HCEMM-SU Molecular Oncohematology Research Group

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Szilvia Krizsan MD

Szilvia Krizsán MD

PUBLICATIONS CONTACT

EDUCATION

2018-: PhD student, Doctoral School of Pathological Sciences, Semmelweis University, 1st Department of Pathology and Experimental Cancer Research, Budapest, Hungary
2012-2018: Doctor of Medicine (summa cum laude), Semmelweis University, Faculty of Medicine, Budapest, Hungary
2007-2012 Karinthy Frigyes Bilingual High School, Budapest

LANGUAGE EXAMS

English – complex, advanced C1 (IELTS, 2012)

SCIENTIFIC ACTIVITY

Research field (PhD, 2018-): Comprehensive genetical characterization of pediatric hematological malignancies (1st Dpt. of Pathology and Experimental Cancer Research, Semmelweis University)
Research field (Medical School, 2016-2018): Prevalence and prognostic implication of WT1 mutation and expression in pediatric acute myeloid leukemia (1st Dpt. of Pathology and Experimental Cancer Research, Semmelweis University)

CONFERENCES

Malignant Lymphoma Conference of the Hungarian Society of Hematology and Transfusion, Debrecen, Hungary, 2018: Screening for genomic copy number alterations in chronic lymphocytic leukemia using multiplex ligation-dependent probe amplification. (Oral presentation)
Mini-symposium on Pediatric Oncology and Hematology, Budapest, Hungary, 2018: Prevalence and prognostic implication of WT1 mutation and expression in pediatric acute myeloid leukemia (Oral presentation)
5th Molecular Hematology Congress of Hungarian Hematology and Transfusiology Society, Kaposvár, Hungary, 2019. Analysis of recurrent genetic abnormalities in acute myeloid leukemia in the context of novel targeted therapies (Oral presentation)
27th Congress of the Hungarian Hematology and Transfusiology Society, Pécs, Hungary, 2019. Analysis of recurrent genetic abnormalities in acute myeloid leukemia in the context of novel targeted therapies (Oral presentation)
European School of Hematology 5th International Conference Acute Myeloid Leukemia “Molecular and Translational”: Advances in Biology and Treatment, Estoril, Portugal, 2019. Mutational profiling of 50 Hungarian pediatric AML patients with next-generation sequencing (Poster presentation)
Semmelweis University, PhD Scientific Days 2020, Budapest, Hungary, 2020. Comprehensive Mutation Screening By Targeted Next-Generation Sequencing in Pediatric Acute Myeloid Leukemia at Diagnosis (Oral presentation) – 1st prize
European School of Hematology 2nd How to Diagnose and Treat: Acute Leukaemia, Online conference, 2020. Trametinib Therapy and Disease Monitoring By Mutation Specific Droplet Digital PCR in Relapsed Pediatric Acute Myeloid Leukemia: A Case Report (Poster presentation)
European School of Hematology 2nd How to Diagnose and Treat: Acute Leukaemia, Online conference, 2020. Comprehensive Mutation Screening By Targeted Next-Generation Sequencing in Pediatric Acute Myeloid Leukemia at Diagnosis (Poster presentation)

TEACHING ACTIVITY

2019-2020 Molecular Oncohematology course, Károly Rácz Doctoral School, lecture and practice
MENTORING BSC AND MD STUDENTS
Zsófia Dénes: BSc project, excellent, 2018
Bence Gerecs: MD project, excellent, 2020
Kotmayer Lili: Semmelweis Scientific Students’ Associations Conference 2020, 2nd prize
Kotmayer Lili: Semmelweis Scientific Students’ Associations Conference 2021, 2nd prize

HONORS

Internal Medicine competition, Semmelweis University, Faculty of Medicine (2017), 1st prize
Scientific Forum of Korányi Frigyes, Semmelweis University (2018), 2nd prize
European School of Hematology Scholarship (2019)
PhD Scientific Days (2020), 1st prize
Semmelweis 250+ Excellence Doctoral Scholarship (2021)

PUBLICATIONS

MTMT ID: 10065846

8. Dissection of subclonal evolution by temporal mutation profiling in chronic lymphocytic leukemia patients treated with ibrutinib.

Gángó, A., Alpár, D., Galik, B., Marosvári, D., Kiss, R., Fésüs, V., Aczél, D., Eyüpoglu, E., Nagy, N., Nagy, Á., Krizsán, S., Reiniger, L., Farkas, P., Kozma, A., Ádám, E., Tasnády, S., Réti, M., Matolcsy, A., Gyenesei, A., Mátrai, Z. and Bödör, C. Int. J. Cancer, 146: 85-93. doi:10.1002/ijc.32502

7. Elevated HOX gene expression in acute myeloid leukemia is associated with NPM1 mutations and poor survival.

Nagy Á, Ősz Á, Budczies J, Krizsán S, Szombath G, Demeter J, Bödör C, Győrffy B. J Adv Res. 2019 Jun 11;20:105-116. doi: 10.1016/j.jare.2019.05.006.

6. Comprehensive profiling of disease-relevant copy number aberrations for advanced clinical diagnostics of pediatric acute lymphoblastic leukemia.

Kiss R, Gángó A, Benard-Slagter A, Egyed B, Haltrich I, Hegyi L, de Groot K, Király PA, Krizsán S, Kajtár B, Pikó H, Pajor L, Vojcek Á, Matolcsy A, Kovács G, Szuhai K, Savola S, Bödör C, Alpár D. Mod Pathol. 2020 May;33(5):812-824. doi: 10.1038/s41379-019-0423-5.

5. Juvenile myelomonocytic leukaemia presentation after preceding juvenile xanthogranuloma harbouring an identical somatic PTPN11 mutation.

Bátai B, Krizsán S, Gángó A, Hegyi L, Csóka M, Erdélyi DJ, Csomor J, Kállay K, Bödör C. Pediatr Blood Cancer. 2020 Sep;67(9):e28368. doi: 10.1002/pbc.28368.

4. Analysis of recurrent genetic abnormalities in acute myeloid leukemia in the context of novel targeted therapies.

Krizsán Szilvia, Dénes Zsófia, Gángó Ambrus, Gerecs Bence, Demeter Judit, Nagy Zsolt, Tárkányi Ilona, Masszi Tamás, Farkas Péter, Masszi András, Szombath Gergely, Benedek Szabolcs, Várkonyi Judit, Horváth Laura, Nagy Zsolt, Radványi Gáspár, Takács István, Hamed Aryan,Lázár Zsolt, Süveges Erzsébet, Kárpáti Ágnes, Plander Márk, Szendrei Tamás, Pál Katalin, Gurzó Mihály, Jakucs János, Egyed Miklós, Bödör Csaba. Hematológia−Transzfuziológia 2019 52:2, 96-105. doi:10.1556/2068.2019.52.2.3

3. CEBPA-mutációk vizsgálata és prognosztikai jelentőségük akut myeloid leukémiában

Ifj. Nagy Béla, Gángó Ambrus, Rejtő László, Krizsán Szilvia, Ujfalusi Anikó, Antal-Szalmás Péter: Hematológia−Transzfuziológia 2019 52:1, 11-17.

2. Akut myeloid leukémiával 2007–2017 között a Semmelweis Egyetem I. sz. Belgyógyászati Klinikán kezelt betegek adatainak elemzése

Raska Alexandra, Krizsán Szilvia, Nagy Zsolt, Demeter Judit, Bödör Csaba, Tárkányi Ilona: Hematológia−Transzfuziológia 2019 52:4, 215-224. doi: 10.1556/2068.2019.52.4.3

1. Genomikus kópiaszám-eltérések szűrése krónikus limfoid leukémiában multiplex ligációfüggő szondaamplifikációval

Kiss Richárd, Papp Gergő, Krizsán Szilvia, Kotmayer Lili, Gángó Ambrus, Nagy Noémi, Bátai Bence, Mátrai Zoltán, Bödör Csaba, Alpár Donát: , Hematológia−Transzfuziológia 2018 51:1, 31-40. doi: 10.1556/2068.2018.51.1.5

HCEMM-SU Molecular Oncohematology Research Group