HCEMM-SU Molecular Channelopathies Research Group

Group Leader

László Csanády

Group Leader

PERSONAL INFORMATION

Family name, First name: László, Csanády
Date of birth: 29/JUL/1971
Researcher unique identifier:
Google Scholar:
ORCID:
URL for web site:

 

Education/Degrees:

1989-1995    Semmelweis University Medical School, Budapest: medicine, M.D. (1995)
1995-2000    The Rockefeller University, New York: biophysics/physiology, Ph.D. (2000)
2016               Hungarian Academy of Sciences: D.Sc. (2016)

 

Positions and Employment:

Semmelweis University, Department of Medical Biochemistry

2018-            Professor

2009-2018    Associate Professor

2007-2009    Assistant Professor

2003-2007    Instructor

2000-2003    Postdoctoral fellow

 

Professional Memberships:

      Biophysical Society (member since 1997)

      Elife (member of board of reviewing editors since 2017)

 

Peer Review Work:

Journals: Journal of General Physiology, Journal of Physiology, British Journal of Pharmacology, Journal of Biological Chemistry, Proc Natl Acad Sci USA, Nat Commun, Elife

Funding agencies: Cystic Fibrosis Trust, Wellcome Trust, Hungarian Scientific Research Fund

 

Awards and Honors:

1992-95  Fellowship of the Hungarian Republic

1995       1st Prize, Student Research Conference (Semmelweis University)

1999       Gosau Young Investigator Award (FEBS Advanced Lecture Course)

2006       Gedeon Richter Research Career Award

2006       János Bolyai Research Fellowship (Hungarian Academy of Sciences)

2008       Tivadar Huzella Award (Semmelweis University)

2010       János Bolyai Research Fellowship (Hungarian Academy of Sciences)

2012       International Early Career Scientist Award (Howard Hughes Medical Institute)

2012       Merit Award (Semmelweis University)

2013       Habilitation (Semmelweis University)

2014       Merit Award (Semmelweis University)

2014       Distinguished Teacher Award (Semmelweis University)

2015       Paul Cranefield Award (Society of General Physiologists)

2016       Doctor of the Hungarian Academy of Sciences (Hungarian Academy of Sciences)

2016       Merit Award (Semmelweis University)

2017       Academy Award (Hungarian Academy of Sciences)

 

Ten most important publications:

  1. Zhang Z, Tóth B, Szollosi A, Chen J, Csanády L. 2018. Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation. Elife 7. pii: e36409.
  2. Sorum B, Töröcsik B, Csanády L. 2017. Asymmetry of movements in CFTR’s two ATP sites during pore opening serves their distinct functions. Elife 6. pii: e29013.
  3. Liu F, Zhang Z, Csanády L, Gadbsy DC, Chen J. 2017. Molecular stucture of the human CFTR ion channel. Cell 169:85-95.
  4. Mihályi, C, Torocsik, B, Csanády, L. 2016. Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerization. Elife 5. pii:e18164. doi:10.7554/eLife.18164., e18164. PMCID:PMC4956468
  5. Iordanov I, Mihályi C, Tóth B, Csanády L. 2016. The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity. Elife 5. pii:e17600. doi:10.7554/eLife.17600., e17600. PMCID:PMC4974056
  6. Sorum, B, Czege, D, Csanády, L. 2015. Timing of CFTR Pore Opening and Structure of Its Transition State. Cell 163, 724-733. PMID:26496611
  7. Tóth, B., Iordanov, I., Csanády, L. 2014. Putative chanzyme activity of TRPM2 cation channel is unrelated to pore gating. Proc. Natl. Acad. Sci. USA. 111:16949-54. PMCID:PMC4250100
  8. Tóth B, Csanády L. 2012. Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents. Proc. Natl. Acad. Sci. USA. 109:13440-5. PMCID:PMC3421201
  9. Csanády, L., Vergani, P., Gadsby, D.C. 2010. Strict coupling between CFTR’s catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations. Proc. Natl. Acad. Sci. USA. 107:1241-1246. PMCID: PMC2824283
  10. Gadsby, D.C., Vergani, P., Csanády, L. 2006. The ABC protein turned chloride channel whose failure causes cystic fibrosis. Nature 440:477-483. PMCID: PMC2720541

 

Ongoing research support:

2017-2022: Hungarian Academy of Sciences Momentum Award

2019-2021: Cystic Fibrosis Foundation Research Grant

2019-2024: Hungarian Center of Excellence for Molecular Medicine Resrach Group Leader Award

 

 

Completed research support:

2017-2019: Cystic Fibrosis Foundation Research Grant

2012-2017: Howard Hughes Medical Institute International Early Career Scientist Award

2015-2017: Cystic Fibrosis Foundation Research Grant

2012-2017: Hungarian Academy of Sciences Momentum Award

2010-2015: National Institutes of Health Research Grant (R01)

2007-2011: Wellcome Trust Project Grant

2007-2011: FIRCA Basic Biomedical (FIRCA-BB)

Publications

  1. Csanády L, Töröcsik, B. 2019. Cystic fibrosis drug ivacaftor stimulates CFTR channels at picomolar concentrations. Elife 8. pii: e46450.
  2. Iordanov I, Tóth B, Szollosi A, Csanády L. 2019. Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates. Elife 8. pii: e44556.
  3. Csanády L, Vergani P, Gadsby DC. 2019. Structure, gating, and regulation of the CFTR anion channel. Physiol Rev. 99:707-738.
  4. Zhang Z, Tóth B, Szollosi A, Chen J, Csanády L. 2018. Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation. Elife 7. pii: e36409.
  5. Martin SL, Saint-Criq V, Hwang TC, Csanády L. 2018. Ion channels as targets to treat cystic fibrosis lung disease. J Cyst Fibros. 17(2S):S22-S27.
  6. Sorum B, Töröcsik B, Csanády L. 2017. Asymmetry of movements in CFTR’s two ATP sites during pore opening serves their distinct functions. Elife 6. pii: e29013.
  7. Csanády L. 2017. A new target for G protein signaling. Elife 6. pii: e29013.
  8. Csanády L. 2017. CFTR gating: Invisible transitions made visible. J Gen Physiol. 149:413-416.
  9. Liu F, Zhang Z, Csanády L, Gadbsy DC, Chen J. 2017. Molecular structure of the human CFTR ion channel. Cell 169:85-95.
  10. Mihályi C, Torocsik B, Csanády L. 2016. Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerization. Elife 5. pii:e18164.
  11. Iordanov I, Mihályi C, Tóth B, Csanády L. 2016. The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity. Elife 5. pii:e17600.
  12. Bársony O, Szalóki G, Türk D, Tarapcsák S, Gutay-Tóth Z, Bacsó Z, Holb IJ, Székvölgyi L, Szabó G, Csanády L, Szakács G, Goda K. 2016. A single active catalytic site is sufficient to promote transport in P-glycoprotein. Sci Rep. 6:24810.
  13. Sorum, B., Czégé, D., Csanády, L. 2015. Timing of CFTR pore opening and structure of its transition state. Cell 163:724-33.
  14. Tóth, B., Iordanov, I., Csanády, L. 2015. Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2′-phosphate. J Gen Physiol. 145:419-430.
  15. Tóth, B., Iordanov, I., Csanády, L. 2014. Putative chanzyme activity of TRPM2 cation channel is unrelated to pore gating. Proc. Natl. Acad. Sci. USA. 111:16949-54.
  16. Csanády, L., Töröcsik B. 2014. Structure-activity analysis of a CFTR channel potentiator: distinct molecular parts underlie dual gating effects. J Gen Physiol. 144:321-336.
  17. Csanády, L., Töröcsik B. 2014. Catalyst-like modulation of transition states for CFTR channel opening and closing: New stimulation strategy exploits nonequilibrium gating. J Gen Physiol. 143:269-287.
  18. Csanády, L., Mihályi C, Szollosi A, Töröcsik B, Vergani P. 2013. Conformational changes in the catalytically inactive nucleotide-binding site of CFTR. J Gen Physiol. 142:61-73.
  19. Vergani P, Gadsby D.C., Csanády, L. 2013. CFTR, an ion channel evolved from an ABC transporter. In:Roberts Gordon (editor); Heidelberg: Springer-Verlag, Encyclopedia of Biophysics 254-265.
  20. Tóth B, Csanády, L. 2012. Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents. Proc Natl Acad Sci U S A. 109:13440-5.
  21. Szollosi, A. , Muallem, D.R., Csanády, L., Vergani, P. 2011. Mutant cycles at CFTR’s non-canonical ATP-binding site support little interface separation during gating. J. Gen. Physiol. 137:549-62.
  22. Csanády, L., Vergani, P., Gulyás-Kovács, A., Gadsby, D.C. 2011. Electrophysiological, biochemical, and bioinformatic methods for studying CFTR channel gating and its regulation. Methods Mol Biol. 741:443-69.
  23. Homolya L., Orbán T.I., Csanády, L., Sarkadi, B. 2011. Mitoxantrone is expelled by the ABCG2 multidrug transporter directly from the plasma membrane. Biochim. Biophys. Acta. 1808:154-163.
  24. Csanády, L., Vergani, P., Gadsby, D.C. 2010. Strict coupling between CFTR’s catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations. Proc. Natl. Acad. Sci. USA. 107:1241-1246.
  25. Tóth B., Csanády, L. 2010. Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel. J. Biol. Chem. 285:30091-102.
  26. Szollosi A., Vergani P., Csanády, L. 2010. Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2. J. Gen. Physiol. 136:407-23.
  27. Csanády, L. 2010. Degenerate ABC composite site is stably glued together by trapped ATP. J. Gen. Physiol. 135:395-398.
  28. Csanády, L. 2010. Permeating proton found guilty in compromising TRPM2 channel activity. J. Physiol. 588:1661-1662.
  29. Csanády, L. 2009. Application of rate-equilibrium free energy relationship analysis to nonequilibrium ion channel gating mechanisms. J. Gen. Physiol. 134:129-136.
  30. Chinopoulos, C., Vajda, Sz., Csanády, L., Mándi, M., Mathe, K., Adam-Vizi, V. 2009. A Novel Kinetic Assay of Mitochondrial ATP-ADP Exchange Rate Mediated by the ANT. Biophys. J. 96:2490-2504.
  31. Csanády, L., Törőcsik, B. 2009. Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate. J. Gen. Physiol. 133:189-203.
  32. Csanády, L., Mindell, J.A. 2008. The twain shall meet: channels, transporters and things between… Meeting on“Membrane Transport in Flux: the ambiguous interface between channels and pumps” EMBO Rep 9:960-965.
  33. Chan, K.W., Wheeler, A., Csanády, L. 2008. Sulfonylurea Receptors Type 1 and 2A Randomly Assemble to Form Heteromeric KATP Channels of Mixed Subunit Composition. J. Gen. Physiol. 131:43-58.
  34. Csanády, L., A.C. Nairn, Gadsby, D.C. 2006. Thermodynamics of CFTR channel gating: a spreading conformational change initiates an irreversible gating cycle. J. Gen. Physiol. 128:523-533.
  35. Fang, K., Csanády, L., Chan, K.W. 2006. The N-terminal transmembrane domain (TMD0) and a cytosolic linker (L0) of sulfonylurea receptor define the unique intrinsic gating of KATP channels. J. Physiol. 576:379-389.
  36. Gadsby, D.C., Vergani, P., Csanády, L. 2006. The ABC protein turned chloride channel whose failure causes cystic fibrosis. Nature 440:477-483.
  37. Csanády, L. 2006. Statistical evaluation of ion-channel gating models based on distributions of LogLikelihood Ratios. Biophys. J. 90:3523-3545.
  38. Csanády, L., Seto-Young, D., Chan, K.W., Cenciarelli, C., Angel, B.B., Qin, J., McLachlin, D.T., Krutchinsky, A.N., Chait, B.T., Nairn, A.C., Gadsby, D.C. 2005. Preferential phosphorylation of R-domain serine 768 dampens activation of CFTR channels by PKA. J. Gen. Physiol. 125:171-186.
  39. Csanády, L., Chan, K.W., Nairn, A.C., Gadsby, D.C. 2005. Functional roles of nonconserved structural segments in CFTR’s NH2-terminal Nucleotide Binding Domain. J. Gen. Physiol. 125:43-55.
  40. Csanády, L., Adam-Vizi, V. 2004. Antagonistic regulation of native Ca2+– and ATP-sensitive cation channels in brain capillaries by nucleotides and decavanadate. J. Gen. Physiol. 123:743-757.
  41. Csanády, L., Adam-Vizi, V. 2003. Ca2+– and voltage-dependent gating of Ca2+– and ATP-sensitive cationic channels in brain capillary endothelium. Biophys. J. 85:313-327.
  42. Csanády, L., Chan, K.W., Seto-Young, D.,  Kopsco, D.C.,  Nairn, A.C.,  Gadsby, D.C. 2000. Severed channels probe regulation of gating of Cystic Fibrosis Transmembrane Conductance Regulator by its cytoplasmic domains. J. Gen. Physiol. 16:477-500.
  43. Chan, K.W., Csanády, L., Seto-Young, D., Nairn, A.C., Gadsby, D.C. 2000. Severed molecules functionally define the boundaries of the Cystic Fibrosis Transmembrane Conductance Regulator’s NH2-terminal nucleotide binding domain. J. Gen. Physiol. 116:163-180.
  44. Csanády, L. 2000. Rapid kinetic analysis of multichannel records by a simultaneous fit to all dwell-time histograms. Biophys. J. 78:785-799.
  45. Csanády, L., Gadsby, D.C. 1999. CFTR channel gating: Incremental progress in irreversible steps. J. Gen. Physiol. 114:49-53.

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