HCEMM-USZ Molecular Gastroenterology Research Group

Group Leader

József Maléth

Group Leader

PERSONAL DETAILS

József Maléth M.D., Ph.D.

Date of birth: 03.02.1983.
Married, one child
Nationality: Hungarian
Phone/Fax: +36-62-545-200
Email: maleth.jozsef@med.u-szeged.hu

EDUCATION

M.D. (2008.), University of Szeged

RESEARCH AND PROFESSIONAL EXPERIENCE

First Dept. of Medicine, University of Szeged – predoctoral research fellow           2012-2013

First Dept. of Medicine, University of Szeged – assistant research fellow               2014-2015

First Dept. of Medicine, University of Szeged – research fellow                              2015-

SCIENTIFIC DEGREE

PhD (2014); summa cum laude; University of Szeged, Theoretical Medicine Doctoral School

Titel of the thesis: Crucial role of pancreatic ducts in the initiation and progression of pancreatitis

INTERNATIONAL RESEARCH EXPERIENCE

EPC Trawelling Fellow; Univ. of Liverpool, UK (PI: Alexei Tepikin); 2011 Jan-Marc (3 months)

Postdoctoral fellow; NIH/NIDCR, Bethesda, USA; (PI: Shmuel Muallem); 2013 January-2014 January (12 months)

Special Volunteer; NIH/NIDCR, Bethesda, USA; (PI: Shmuel Muallem); 2014 January (1 months)

MEMBERSHIPS AND POSITIONS

Member of the Hungarian Gastroenterological Society (2007-)

Member of the European Pancreatic Club (2009-)

Assistant Secretary of the European Pancreatic Club (2012-)

International Association of Pancreatology (2009-)

American Pancreatic Association (2015-)

United European Gastroenterology (2011-)

Hungarian Physiological Society (2015-)

SCIENTIFIC AWARDS/PRIZES

Junior Prima Prize (2016)

HAS János Bólyai Research Fellowship (2016)

Rolf Madaus Prize (Hungarian Gastroenterological Society) (2016)

Young Investigator Award of the HAS (2016)

HAS SZAB Regional Competition First Prize (2015)

Rolf Madaus Prize (Hungarian Gastroenterological Society) (2015)

Best oral presentation (European Pancreatic Club Meeting) (2014)

Ányos Jedlik Predoctoral Scholarship (2013)

Imre Magyar Prize of the Hungarian Gastroenterological Society (2012)

Third Prize Student Competition Assay, Szeged, Hungary (2008)

First Prize Student Competition Assay, Szeged, Hungary (2007)

Second Prize Student Competition Assay, Szeged, Hungary (2007)

Third Prize Student Competition Assay, Szeged, Hungary (2006)

SCIENTIFIC INTEREST

Epithelial signaling and secretion with a special focus on cAMP and Ca2+ signalization and their interactions. The composition and function of organellar contact sites in polarized cell physiology. The physiological and pathological roles of CFTR channel in cell and organ physiology. New organoid models in the gastrointestinal research and their translational potential. Microscopy techniques in epithelial research (super-resolution, correlative microscopy, scanning electron microscopy), 3D imaging modalities (array tomography). Inflammatory diseases in the gastrointestinal tract (acute pancreatitis, inflammatory bowel diseases).

MAIN RESEARCH GRANTS` AS PRINCIPAL INVESTIGATOR OR AS PROJECT LEADER

1) Hungarian Academy of Sciences: LENDULET_2017-254; PI: József Maléth; Project title: Assembly and physiological role of the endoplasmic reticulum/plasma membrane microdomain in polarized epithelial cells, Duration: 2017-2022; Budget of the Project: 635 000 Euros

2) EU’s Horizon 2020 research and innovation program (Hungarian Centre of Excellene for Molecular Medicine): Grant agreement No. 739593.; Project title: Patient-derived ex vivo PancREatic organoiD cocultures as disease-specific models in trAnslaTiOnal Research Duration: 2020-2025; Budget of the Project: ~340 000 Euros

3) Ministry of Human Capacities: EFOP 3.6.2-16-2017-00006; Project title: Utilization of translational medicine to improve the severity and mortality of life threatening acute diseases; Period: 2017-2020; Amount (in Euros): 127 000

4) National Research, Development and Innovation Ofice: UNKP/IKK-20391-3/2018/ FEKUSTRAT; Project title: Therapeutic developments – Translational biomedicine; Period: 2018-2019; Amount (in Euros): 98 500

5) National Research, Development and Innovation Office (NKFIH): Utilization of translational medicine to improve the severity and mortality of life threatening acute diseases – STAY ALIVE; GINOP 2.3.2.-15-2016-00048; PI: Péter Hegyi; Project leader: József Maléth; Duration: 20017-2021; Budget of the Project: 48,345e HUF; Total budget: 1494 MFt

6) Hungarian Academy of Science: Assembly and physiological role of the endoplasmic reticulum/plasma membrane microdomain in polarized epithelial cells; Bólyai Research Fellowship; BO/00440/16/5; PI: József Maléth; Duration:2016-2019; Budget: 4,482e HUF

7) Hungarian Scientific Research Fund (OTKA): Assembly and physiological role of the endoplasmic reticulum/plasma membrane microdomain in polarized epithelial cells; OTKA PD115974; PI: József Maléth; Duration:2015-2018; Budget: 26,058e HUF

8) NKTH TÁMOP: TÁMOP-4.2.2.A-11/1/KONV-2012-0035; PI: Lajos Kemény – Péter Hegyi; Project leader: Péter Hegyi – József Maléth; Duration: 2008-2011; Budget of the Project: 40 000e HUF; Total budget: 620 MFt

MAIN RESEARCH GRANTS` AS PARTICIPANT

1) Hungarian Scientific Research Fund (OTKA): The pathophysiology of pancreatic ductal bicarbonate secretion. NNF 78851 2009-2011 PI: Péter Hegyi, Budget: 29853e HUF

2) NKTH ASBÓTH 2005-2009, PI: János Lonovics, Budget: 38000e HUF

3) Hungarian Scientific Research Fund (OTKA): New therapeutical approach in acute pancreatitis; NF 100677 2012-2014, PI: Péter Hegyi, Budget: 39024e HUF

4) Hungarian Scientific Research Fund (OTKA): Investigation of the early phase of acute and chronic pancreatitis: from bed to the bench side research; K116634 2015-2019; PI: Péter Hegyi; Budget: 43152e HUF

5) Hungarian Scientific Research Fund (OTKA): Association between serum, mucosal and fecal infliximab levels and response to anti TNF-α therapy in patients with inflammatory bowel disease – new insights into the mechanism of loss of response to biological therapy; K116634 2015-2019; PI: Klaudia Farkas  Budget: 28113e HUF

REVIEWER AND EDITORIAL ACTIVITY

Journal of Pancreas (ass. editor)

Pancreatology

Cell Calcium

Journal of Pancreas

PLOS One

Digestive Diseases and Sciences

ACTIVE INTERNATION   AL COLLABORATIONS

Dr. M.A. Gray (University of Newcastle, UK) 2010-

Prof. Markus Lerch (University of Greifswald, Germany) 2013-

Prof. Gergely Lukács (McGill University, Montreal, Canada) 2013-

Prof. Shmuel Muallem (National Institutes of Health) 2014-

Prof. Alexander Kleger (University of Ulm, Germany) 2016-

János Almássy (Dept. of Physiology, Univ. of Debrecen) 2016-

Miklós Erdélyi (SZTE TTIK) 2017-              

Ph.D. COMMITTEE MEMBER:

Year – Position- Name of the Candidate- University

2016 – referee- József Tóth- SOTE, Budapest, Hungary

2016 – referee – Orsolya Hegyesi – SOTE, Budapest, Hungary

2016 – referee – Erzsébet Bori – SOTE, Budapest, Hungary

Ph.D. STUDENT SUPERVISOR:

Júlia Fanczal 2015- (50%)

Emese Tóth 2015- (50%)

Marietta Görög 2016-

Réka Molnár 2016-

http://www.doktori.hu/index.php?menuid=192&lang=HU&sz_ID=20320

STUDENT RESEARCH FELLOW’S SUPERVISOR:

Number of student fellows: 8

Number of presentations at student competitions: 6

Number of first prizes: 1; Tamara Madácsy (2016)

SCIENTOMETRICS

Total number of publications: 40

Cumulative impact factor: 238.116

Total citations (MTMT): 824

Independent citations: 529

Hirsch index (MTMT): 18

Q1/D1 ranked publications: 22

Full publication list: https://vm.mtmt.hu//search/slist.php?lang=0&top10=0&AuthorID=10030084

TOP 5 PUBLICATIONS FROM THE LAST 5 YEARS

  1. Maléth J, Choi S, Muallem S, Ahuja M. Translocation Between PI(4,5)P2-Poor and PI(4,5)P2-Rich Microdomains During Store Depletion Determines STIM1 Conformation and Orai1 Gating. Nature Communications 2014 Dec 17;5:5843. doi: 10.1038/ncomms6843. [IF: 11.470];
  2. Maléth J, Balla Z, Kui B, Balázs A, Katona M, Judák L, Németh I, Pallagi P, Kemény LV, Rakonczay Jr. Z, Venglovecz V, Földesi I, Pető Z, Somorácz Á, Borka K, Perdomo D, Lukacs GL, Gray MA, Monterisi S, Zaccolo M, Sendler M, Mayerle J, Kühn JP, Lerch MM, Sahin-Tóth M, Hegyi P. Alcohol Disrupts Levels and Function of the Cystic Fibrosis Transmembrane Conductance Regulator to Promote Development of Pancreatitis. Gastroenterology 2015 Feb;148(2):427-39.e16. [IF: 18.187];
  3. Jha A, Ahuja M, Maléth J, Moreno CM, Yuan JP, Kim MS, Muallem S. The STIM1 CTID domain determines access of SARAF to SOAR to regulate Orai1 channel function. J Cell Biol. 2013 8;202(1):71-9 [IF: 9.688];
  4. Pallagi P, Venglovecz V, Rakonczay Z Jr, Borka K, Korompay A, Ózsvári B, Judák L, Sahin-Tóth M, Geisz A, Schnúr A, Maléth J, Takács T, Gray MA, Argent BE, Mayerle J, Lerch MM, Wittman T, Hegyi P. Trypsin reduces pancreatic ductal bicarbonate secretion by inhibiting CFTR Cl− channels and luminal anion exchangers. Gastroenterology 2011;141, 2228–2239.e6. [IF: 11.675];
  5. Maléth J, Venglovecz V, Rázga Zs, Tiszlavicz L, Rakonczay Z, Hegyi P. The non-conjugated chenodeoxycholate induces severe mitochondrial damage and inhibits bicarbonate transport in pancreatic duct cells. Gut 2011; 60(1):136-8. [IF: 10.111];

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