HCEMM-SU Extracellular Vesicles Research Group

Group Leader

Edit Buzás

Group Leader

PERSONAL INFORMATION

Family name, First name: Buzás, Edit Irén
Researcher unique identifier(s): ORCID ID 0000-0002-3744-206X
Google Scholar ID: 0bILSNgAAAAJ
Scopus ID: 7004693063
ResearchGate: Edit_Buzas2
Homepage: http://extracellularvesicles.org/
Nationality: Hungarian
URL for website: http://www.gsi.semmelweis.hu/index.php/en/research/research-groups/extracellularvesicles

EDUCATION

1996 PhD
Faculty of General Medicine/ Department of Anatomy, Histology and Embriology, University of Debrecen / Hungary, Professor Tibor T Glant (PhD Supervisor)
1983 University diploma
Faculty of General Medicine/ University of Szeged/ Szeged, Hungary

CURRENT POSITION(S)

2012 – Chair: Department of Genetics, Cell- and Immunbiology, Semmelweis University, Hungary
2011 – Professor: Semmelweis University, Hungary

PREVIOUS POSITIONS

2006- : Head of the Extracellular Vesicle Research Group in the Department of Genetics, Cell- and Immunbiology
1998-2006: Assistant and Associate Professor at the Department of Genetics, Cell- and Immunbiology, Semmelweis University, Hungary
1983-1998: Research Associate and Assistant Professor at the Department of Anatomy, Histology and Embriology at the University of Debrecen

FELLOWSHIPS

1997-1998 Visiting Assistant Professor, Departments of Biochemistry and Orthopedic Surgery/ Rush University, Chicago, IL, USA
1987 – 1989 Visiting Scientist, Shriners Hospital for Crippled Children, McGill University, Montreal, Kanada

SUPERVISION OF GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS

1993-2018 supervised 6 Postdocs/ 9 PhD students (supervised until graduation), 1 PhD is before defense/ supervised 21 Master Students
Name of Faculty/ Department/ Centre, Name of University/ Institution/ Country

TEACHING ACTIVITIES

1983-1998 –Teaching position – Anatomy, Histology and Immunobiology Topic, Debrecen University/ Hungary
1998- Positions: Assistant, later Associate and from 2006 Professor /Subjects: Basic Cell Biology, Immunology and Genetics and Genomics at Semmelweis University Hungary

ORGANIZATION OF SCIENTIFIC MEETINGS

2020 VICE CHAIR Extracellular Vesicles Gordon Research Conference (location to be determined later)
2019 Member of the International Organizing Committee: 8th Annual Meeting of ISEV (ISEV2019) Kyoto, Japan
2018 Member of the International Organizing Committee: 7th Annual Meeting of ISEV (ISEV2018) Barcelona, Spain
2018 Member of the Scientific Program Committee, European Congress of Immunology (ECI) 2018, Amsterdam, The Netherlands
2017 Member of the International Organizing Committee 6th Annual Meeting of ISEV (ISEV2017) Toronto, Canada
2016 CHAIR: 5th Annual Meeting of ISEV (ISEV2016) Rotterdam, The Netherlands
2013 CHAIR: International Society for Extracellular Vesicles (ISEV) Workshop on Isolation and Characterization of Extracellular Vesicles, Hungary

INSTITUTIONAL RESPONSIBILITIES

2011 – Professor and Chair at Semmelweis University, Budapest, Hungary
2012 – Head of the Department of Genetics, Cell- and Immunobiology at Semmelweis University, Budapest, Hungary
2012 – Member of the Curriculum Committeee and head of the Quality Insurance Committee of the Faculty of General Medicine at Semmelweis University
2017 – Member of the Senate of Semmelweis University

COMMISSIONS OF TRUST

1999-2002 & 2008-2011 OTKA Hungarian Scientific Research Fund (OTKA)
Infraindividual Panel: MEMBER
2011-1015 OTKA National Research, Development and Innovation Office
Infraindividual Panel: CHAIR
2017-2020 OTKA Higher Panel (OTKA Kollégium)
2012 – Editorial Board, Associate Editor of the Journal of Extracellular Vesicles (Francis & Taylor)
2017 – Reviewer, Utrecht University/ The Netherlands
2013 – European Research Council Consolidator Panel members

MEMBERSHIPS OF SCIENTIFIC SOCIETIES

2013 – Henry Kunkel Society, Rockefeller University, NYC, USA (2013-)
2011 – Founding Member of the International Society for Extracellular Vesicles
(2014-) International Society for Extracellular Vesicles Board of Directors – member
(2016-2018 and 2018-2020) International Society for Extracellular Vesicles elected Officer: Executive Chair Education
(2013-2017) European Network on Exosomes and Microvesicles COST H2020 Network WG leader
Henry Kunkel Society (2013-)
2017- 2020 TRAIN EV (Training in Extracellular Vesicles: For Benefit in Health and Disease Marie Sklodowska Curie ITN – PI
2011-2016 PI of FP7-PEOPLE-2011-ITN – Marie-Curie Action: “Initial Training Networks” DYNANO
2006-2009 PI of MOBILITY-1.1 – Marie Curie Research Training Networks (RTN) DYNAMIC

Publications

  1. Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA. Németh A, Orgovan N, Sódar BW, Osteikoetxea X, Pálóczi K, Szabó-Taylor KÉ, Vukman KV, Kittel Á, Turiák L, Wiener Z, Tóth S, Drahos L, Vékey K, Horvath R, Buzás EI.Sci Rep. 2017 Aug 15;7(1):8202.
  2. Monocyte activation drives preservation of membrane thiols by promoting release of oxidised membrane moieties via extracellular vesicles. Szabó-Taylor KÉ, Tóth EÁ, Balogh AM, Sódar BW, Kádár L, Pálóczi K, Fekete N, Németh A, Osteikoetxea X, Vukman KV, Holub M, Pállinger É, Nagy G, Winyard PG, Buzás EI. Free Radic Biol Med. 2017 Jul;108:56-65.
  3. Methodological Guidelines to Study Extracellular Vesicles. Coumans FAW, Brisson AR, Buzas EI, Dignat-George F, Drees EEE, El-Andaloussi S, Emanueli C, Gasecka A, Hendrix A, Hill AF, Lacroix R, Lee Y, van Leeuwen TG, Mackman N, Mäger I, Nolan JP, van der Pol E, Pegtel DM, Sahoo S, Siljander PRM, Sturk G, de Wever O, Nieuwland R.Circ Res. 2017 May 12;120(10):1632-1648.
  4. Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection. Sódar BW, Kittel Á, Pálóczi K, Vukman KV, Osteikoetxea X, Szabó-Taylor K, Németh A, Sperlágh B, Baranyai T, Giricz Z, Wiener Z, Turiák L, Drahos L, Pállinger É, Vékey K, Ferdinandy P, Falus A, Buzás EI. Sci Rep. 2016 Apr 18;6:24316.
  5. Improved characterization of EV preparations based on protein to lipid ratio and lipid properties.Osteikoetxea X, Balogh A, Szabó-Taylor K, Németh A, Szabó TG, Pálóczi K, Sódar B, Kittel Á, György B, Pállinger É, Matkó J, Buzás EI. PLoS One. 2015 Mar 23;10(3):e0121184.Andrea Németh, Norbert Orgovan, Barbara W Sódar, Xabier Osteikoetxea, Krisztina Pálóczi, Katalin É Szabó-Taylor, Krisztina V Vukman, Ágnes Kittel, Lilla Turiák, Zoltán Wiener, Sára Tóth, László Drahos, Károly Vékey, Robert Horvath, Edit I Buzás Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA SCIENTIFIC REPORTS 7:(1) Paper 8202. 16 p. (2017)
  6. Sodar BW, Kittel A, Paloczi K, Vukman KV, Osteikoetxea X, Szabo-Taylor K, Nemeth A, Sperlagh B, Baranyai T, Giricz Z, Wiener Z, Turiak L, Drahos L, Pallinger E, Vekey K, Ferdinandy P, Falus A, Buzas EI Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection SCIENTIFIC REPORTS 6: Paper 24316. 12 p. (2016)
  7. Osteikoetxea X, Balogh A, Szabo-Taylor K, Nemeth A, Szabo TG, Paloczi K, Sodar B, Kittel A, Gyorgy B, Pallinger E, Matko J, Buzas EI Improved Characterization of EV Preparations Based on Protein to Lipid Ratio and Lipid Properties. PLOS ONE 10:(3) Paper e0121184. (2015)
  8. Edit Buzas, Bence György, György Nagy, András Falus, Steffen Gay
    Emerging role of extracellular vesicles in inflammatory diseases NATURE REVIEWS RHEUMATOLOGY 10:(6) pp. 356-364. (2014)
  9. Szabo GT, Tarr B, Paloczi K, Eder K, Lajko E, Kittel A, Toth S, Gyorgy B, Pasztoi M, Nemeth A, Osteikoetxea X, Pallinger E, Falus A, Szabo-Taylor K, Buzas EI Critical role of extracellular vesicles in modulating the cellular effects of cytokines CELLULAR AND MOLECULAR LIFE SCIENCES 71:(20) pp. 4055-67. (2014)
  10. Gyorgy B, Szabo TG, Turiak L, Wright M, Herczeg P, Ledeczi Z, Kittel A, Polgar A, Toth K, Derfalvi B, Zelenak G, Borocz I, Carr B, Nagy G, Vekey K, Gay S, Falus A, Buzas EI Improved Flow Cytometric Assessment Reveals Distinct Microvesicle (Cell-Derived Microparticle) Signatures in Joint Diseases
    PLOS ONE 7:(11) Paper e49726. 8 p. (2012)
  11. Gyorgy B, Modos K, Pallinger E, Paloczi K, Pasztoi M, Misjak P, Deli MA, Sipos A, Szalai A, Voszka I, Polgar A, Toth K, Csete M, Nagy G, Gay S, Falus A, Kittel A, Buzas EI Detection and isolation of cell-derived microparticles are compromised by protein complexes resulting from shared biophysical parameters BLOOD 117:(4) pp. E39-E48. (2011)
  12. Gyorgy B, Szabo TG, Pasztoi M, Pal Z, Misjak P, Aradi B, Laszlo V, Pallinger E, Pap E, Kittel A, Nagy G, Falus A, Buzas EI Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles CELLULAR AND MOLECULAR LIFE SCIENCES 68:(16) pp. 2667-2688. (2011)
  13. Fitzpatrick L A, Buzas E, Gagne T J, Nagy A, Horvath C, Ferencz V, Mester A, Kari B, Ruan M, Falus A, Barsony J Targeted deletion of histidine decarboxylase gene in mice increases bone formation and protects against ovariectomy-induced bone loss PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA100:(10) pp. 6027-6032. (2003)
  14. Buzas EI, Brennan FR, Mikecz K, Garzo M, Negroiu G, Hollo K, Cs-Szabo G, Pintye E, Glant TT
    A proteoglycan (aggrecan)-specific T cell hybridoma induces arthritis in BALB/c mice.
    JOURNAL OF IMMUNOLOGY 155:(5) pp. 2679-2687. (1995)

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