HCEMM-BRC Translational Microbiology Research Group

Group Leader

Bálint Kintses

Group Leader

PERSONAL INFORMATION

Family name, First name: Bálint Kintses
Researcher unique identifier(s):

ORCID: 0000-0003-0844-0310

Google Scholar: gax-6nEAAAAJ

Nationality: Hungarian

 

EDUCATION

2009 PhD, Faculty of Biochemistry/Eotvos Lorand University, Hungary/Supervisor: Andras Malnasi-Csizmadia
2005 MSc in Biology/Department of Biochemistry/Eotvos Lorand University, Hungary
CURRENT POSITION
2016 – 2019 Group Leader
Synthetic and Systems Biology Unit/Institute of Biochemistry/
Biological Research Centre, Szeged (BRC),Hungary
2016 – 2019 Junior Group Leader
H-CEMM / Hungarian Centre of Excellence for Molecular Medicine

 

PREVIOUS POSITIONS

2016 – 2019 Senior Research Associate Csaba Pál laboratory, Synthetic and Systems Biology Unit/Institute of Biochemistry/ Biological Research Centre (BRC),Hungary

2013 – 2016 Postdoctoral Scientist, Csaba Pál laboratory, Synthetic and Systems Biology Unit/Institute of Biochemistry/ Biological Research Centre (BRC),Hungary

2009 – 2012 Postdoctoral Scientist (Marie Sklodowska-Curie Fellow) Department of Biochemistry/University of Cambridge, UK

2005 – 2008 PhD student Department of Biochemistry/Eotvos Lorand University, Hungary

 

FELLOWSHIPS

2018 – 2019 New National Excellence Program Bolyai Plus Research Fellowship, BRC, Hungary

2016 – 2019 Bolyai János Research Fellowship of the Hungarian Academy of Sciences, BRC, Hungary

2013 – 2015 Hungarian Scientific Research Fund Postdoctoral Fellowship, BRC, Hungary

2009 – 2012 Marie Sklodowska-Curie Postdoctoral Fellowship/Department of Biochemistry/ University of Cambridge, UK

2005 – 2008 PhD State Fellowship, Eotvos Lorand University, Hungar

 

AWARDS

Postdoctoral Scientist (Marie Sklodowska-Curie Fellow) Department of Biochemistry/University of Cambridge, UK
PhD student
Department of Biochemistry/Eotvos Lorand University, Hungary
New National Excellence Program Bolyai Plus Research Fellowship, BRC, Hungary Bolyai János Research Fellowship of the Hungarian Academy of Sciences, BRC, Hungary
Hungarian Scientific Research Fund Postdoctoral Fellowship, BRC, Hungary
Marie Sklodowska-Curie Postdoctoral Fellowship/Department of Biochemistry/ University of Cambridge, UK
PhD State Fellowship, Eotvos Lorand University, Hungar
2016 Hungarian Academy of Sciences, Academic Young Investigator Award
2010 Best Poster Award, Novel Enzymes Conference, Exeter, UK
2007 Young Scientist Award, IV. International Conference on Molecular Recognition

 

ONGOING GRANTS

Project title: Exploring the risk of horizontal gene transfer between the human microbiome and pathogenic bacteria
Funding source: National Research, Development and Innovation Office (NKFIH), Hungary
Project title: Aiding the Development of Precision Anti-virulence Therapy for Inflammatory Bowel Disease
Funding source: H-CEMM / Hungarian Centre of Excellence for Molecular Medicine / European Union’s Horizon 2020 research and innovation programme under grant agreement No 739593

 

SCIENTOMETRY

Number of publications: 20
Number of D1 publications: 20
Number of first and last authored publications: 8
Number of D1 first and last authored publications: 8 Number of citations: 600 (Web of Science), 991 (Google Scholar) Hirsch index: 11 (Web of Science), 14 (Google Scholar)
Number of Book chapters: 2 Other relevant indicators:
Many of my papers were published in high ranked journal such as: Nature Microbiology (2), Nature Structural and Molecular Biology (2), PNAS (4), Nature Communications (1, 2 manuscripts are currently under review), Current Opinion in Biotechnology (1), Current Opinion in Chemical Biology (1), EMBO Journal (1).

 

PATENTS

Nyerges A, Pal C, Csorgo B, Kintses B Mutagenizing Intracellular Nucleic Acids PCT/EP2017/082574,

 

TEACHING ACTIVITIES

2018 – Lecturer/Bioinformatics of OMICS approaches PhD course – University of Szeged/ Department of Biochemistry and Molecular Biology/ Hungary
2005 – 2008 Assistant Lecturer/ Biochemistry Practical Course/Eotvos University/Department of Biochemistry, Hungary

 

INSTITUTIONAL RESPONSIBILITIES

2018 – PhD Student Advisor, University of Szeged/PhD school of Biology/Hungary

 

SELECTED INTERNATIONAL PRESENTATIONS

Phylogenetic barriers to horizontal transfer of antimicrobial peptide resistance genes in the human gut microbiome.

Gordon Research conference, 2019

Phylogenetic barriers to horizontal transfer of antimicrobial peptide resistance genes in the human gut microbiome.
Sixth International Symposium on Antimicrobial Peptides, 2018, Poitiers, France

Forecasting Evolutionary Adaptation by Mapping the Innovative Potential of Underground Metabolism. Annual meeting of the Society for Molecular Biology and Evolution, 2015, Vienna, Austria

Directed enzyme evolution: to put through highly or not? II ChemProEng Meeting, 2011, Cambridge, UK

Communication between the actin binding site and the relay region of myosin: the molecular mechanism of actin activation.
XXXVII European Muscle Conference 2008, Oxford, UK

Reversible movement of switch 1 loop of myosin determines actin interaction. 
 IV. International Conference on Molecular Recognition 2007, Pecs, Hungary

Reversible movement of switch 1 loop of myosin determines actin interaction. 7. 
 Young Scientist Forum 2007, Vienna, Austria

Publications

LIST OF 5 KEY PUBLICATIONS FROM THE LAST 5 YEARS

(Corresponding authorship is indicated with my name underlined, first authorship with a start)

  1. Kintses B*, Kumar P Jangir , Fekete G, Számel M, Méhi O, Spohn R, Daruka L, Martins A, Hosseinnia A, Gagarinova A, Kim S, Phanse S, Csörgö B, Györkei A, Ari E, Lázár V, Faragó A, Bodai L, Nagy I, Babu M, Pál C, Papp B Chemical-genetic profiling reveals cross-resistance and collateral sensitivity between antimicrobial peptides Nature Communications 10 (1) 1-13
  2. Kintses B*, Méhi O, Ari E, Számel M, Györkei Á, Jangir PK, Nagy I, Pál F, Fekete G, Tengölics R,
    Nyerges Á, Likó I, Bálint A, Molnár T, Bálint B, Vásárhelyi BM, Bustamante M, Papp B, Pál C. Phylogenetic barriers to horizontal transfer of antimicrobial peptide resistance genes in the human gut microbiota. Nature Microbiology 2018 Dec 17. doi: 10.1038/s41564-018-0313-5. Citations: 1 (Google Scholar), 1 (Web of Science)
  3. Nyerges Á, Csörgő B, Draskovits G, Kintses B, Szili P, Ferenc G, Révész T, Ari E, Nagy I, Bálint B, Vásárhelyi BM, Bihari P, Számel M, Balogh D, Papp H, Kalapis Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance. Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5726-E5735. Citations: 5 (Google Scholar), 2 (Web of Science)
  4. Colin PY, Kintses B, F Gielen, C Miton, G Fischer, M Mahomed, M Hyvonen, DP, Morgavi, DB, Janssen, F Hollfelder. Ultrahigh-throughput Discovery of Promiscuous Enzymes by Picodroplet Functional Metagenomics Nature Communications, 2015, Dec 7, 6:10008. Citations: 82 (Google Scholar), 65 (Web of Science)
  5. Notebaart RA, Szappanos B, Kintses B* , Pál F, Györkei Á, Bogos B, Lázár V, Spohn R, Csörgő B, Wagner A, Ruppin E, Pál C, Papp B. Network-level architecture and the evolutionary potential of underground metabolism. Proc Natl Acad Sci U S A. 2014, 111(32):11762-7. Citations: 68 (Google Scholar), 51 (Web of Science)

LIST OF OTHER KEY PUBLICATIONS (whole career)

  1. B Kintses*, Hein C, Mohamed MF, Fischlechner M, Courtois F, Laine C, Hollfelder F. Picoliter cell lysate assay in microfluidic droplet compartments for directed enzyme evolution, Chemistry and Biology, 2012, 19(8), 1001-9. Citations: 127 (Google Scholar), 89 (Web of Science)
  2. B. Várkuti, Z. Yang, B Kintses, P Erdélyi, I Bárdos-Nagy, A.L. Kovács, P. Hári, M. Kellermayer, T Vellai, A Málnási- Csizmadia. A novel actin binding site of myosin enables effective muscle contraction, Nature Structural and Molecular Biology 2012, 19 (3), 299-306. Citations: 46 (Google Scholar), 31 (Web of Science)
  3. B. Kintses*, L. van Vliet, S. Devenish, F. Hollfelder, Microfluidic Droplets: New Integrated Workflows for Biological Experiments, 
 Current Opinion in Chemical Biology 2010, 14 (5), 548-55. Citations: 153 (Google Scholar), 99 (Web of Science)
  4. D, Papp B, Pál C. B. Kintses*, M. Gyimesi, W. Zeng, D. Pearson, M. Geeves, CR. Bagshaw, A. Malnasi-Csizmadia, Reversible movement of switch 1 loop of myosin determines actin interaction, EMBO Journal., 2007, 26(1):265-74. Citations: 56 (Google Scolar), 38 (Web of Science)
  5. Zinchenko A, Devenish SR, Kintses B, Colin PY, Fischlechner M, Hollfelder F. One in a million: flow cytometric sorting of single cell-lysate assays in monodisperse picolitre double emulsion droplets for directed evolution. Analytical Chemistry. 2014, 86(5):2526-33. Citations: 82 (Google Scholar), 61 (Web of Science)
  6. B. Kintses*, Z. Yang, A. Malnasi-Csizmadia, Experimental investigation of the seesaw mechanism of the relay region that moves the myosin lever arm, Journal of Biological Chemistry., 2008, 283(49):34121-8. Citations: 23 (Google Scholar), 14 (Web of Science)
  7. Lázár V, Martins A, Spohn R, Daruka L, Grézal G, Fekete G, Számel M, Jangir PK, Kintses B, Csörgő B, Nyerges Á, Györkei Á, Kincses A, Dér A, Walter FR, Deli MA, Urbán E, Hegedűs Z, Olajos G, Méhi O, Bálint B, Nagy I, Martinek TA, Papp B, Pál C. Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides. Nature Microbiology 2018 Jun;3(6):718-731. Citations: 16 (Google Scolar), 7 (Web of Science)
  8. Notebaart RA, Kintses B, Feist AM, Papp B. Underground metabolism: network-level perspective and biotechnological potential. Current Opinion Biotechnology., 2018, Feb; 49:108-114. Citations: 14 (Google Scholar), 11 (Web of Science)
  9. Natan E, Endoh T, Haim-Vilmovsky L, Flock T, Chalancon G, Hopper JTS, Kintses B, Horvath P, Daruka L, Fekete G, Pál C, Papp B, Oszi E, Magyar Z, Marsh JA, Elcock AH, Babu MM, Robinson CV, Sugimoto N, Teichmann SA. Cotranslational protein assembly imposes evolutionary constraints on homomeric proteins. Nature Structural and Molecular Biology 2018 Mar;25(3):279-288. Citations: 5 (Google Scholar), 0 (Web of Science)

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