HCEMM-BRC Mutagenesis and Carcinogenesis Research Group

Group Leader

Lajos Haracska

Group Leader

PERSONAL INFORMATION

Family name, First name: Haracska, Lajos
Researcher unique identifier, ORCID: https://orcid.org/0000-0003-3608-5897
Nationality: Hungarian
URL for web site: http://www.brc.hu/gen_mutagenesis_and_carcinogenesis.php

EDUCATION

2012 D.Sc., Hungarian Academy of Sciences
1997 PhD in Biology, University of Szeged
1991 M.Sc., Molecular Biologist and Biotechnologist, Attila József University of Sciences, Szeged

CURRENT POSITION(S)

2006 – Scientific advisor, Leader of the mutagenesis and carcinogenesis research group
Institute of Genetics/Biological Research Centre

PREVIOUS POSITIONS

2003-2006 Research group leader
Institute of Genetics/ Biological Research Centre
1998-2003 Postdoctoral fellow
Sealy Center for Molecular Sciences, Galveston, TX, USA
1997-1998 Postdoctoral fellow
The University of Dundee, UK
1991-1997 PhD student
Institute of Biochemistry/ Biological Research Centre

FELLOWSHIPS

2005 The Howard Hughes Medical Institute international fellowship (5-yr-term)
2004 Marie Curie research fellowship, EU FP6 (3-yr-term)
2003 Wellcome Trust International Senior Research Fellowship (5-yr-term)
1998 EMBO fellowship
1997 FEBS fellowship

SUPERVISION OF GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS

2003 – 2018 10 Postdocs/ 8 PhD/ 12 Master Students
University of Szeged/Hungary

COMMISSIONS OF TRUST

2015- ERC LSI grant panel member
2013- Representative of the Hungarian Academy of Sciences/Hungary
2008- Member of the board of OTKA grant agency/Hungary

MEMBERSHIPS OF SCIENTIFIC SOCIETIES

2015- Member of the Doctoral Council of the Hungarian Academy of Sciences
2015- Vice secretary of the Hungarian Biochemical Society
2012- Member of the Section of Biological Sciences
2012- Member of the Comittee on Genetics, Cellular Biology and Molecular Biology
2006- Member of the Hungarian Genetical Society
2004- Member of the Hungarian Biochemical Society

AWARDS & DECORATIONS

2017 Szent-Györgyi Talentum Award

2015 Straub Award
2014 Szentágothai János Award
1997 Excellent Young Researcher Award, Hungarian Academy of Sciences

SCIENTOMETRY

Number of publications 71
Number of D1 and Q1 publications
D1:62 Q1:3 (starting from 1999; this classification did not exist before 1999)
Number of first and last authored publications
First author: 20 Last author:14
Number of D1 and Q1 first and last authored publications
D1(first): 16 Q1(first): – (the others are earlier than 1999)
D1(last):13 Q1(last): 1
Number of citations: 4944 (sum) 4178 (independent)
Hirsch index: 40
Other relevant indicator(s): sum impact factor: 603.966

Publications

  1. Characterization of human Spartan/C1orf124, an ubiquitin-PCNA interacting regulator of DNA damage tolerance. Juhasz S, Balogh D, Hajdu I, Burkovics P, Villamil MA, Zhuang Z, Haracska LNucleic Acids Res. 2012 Nov;40(21):10795-808. doi: 10.1093/nar/gks850. PMID: 22987070
  2.  Coordinated protein and DNA remodeling by human HLTF on stalled replication fork. Achar YJ, Balogh D, Haracska L. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14073-8. doi: 10.1073/pnas.1101951108. PMID: 21795603
  3. Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination. Unk I, Hajdú I, Fátyol K, Hurwitz J, Yoon JH, Prakash L, Prakash S, Haracska L. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3768-73. doi: 10.1073/pnas.0800563105. PMID: 18316726
  4. Yeast Rad5 protein required for postreplication repair has a DNA helicase activity specific for replication fork regression. Blastyák A, Pintér L, Unk I, Prakash L, Prakash S, Haracska LMol Cell. 2007 Oct 12;28(1):167-75. PMID: 17936713
  5. Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen. Unk I, Hajdú I, Fátyol K, Szakál B, Blastyák A, Bermudez V, Hurwitz J, Prakash L, Prakash S, Haracska L. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18107-12. PMID: 17108083 
  6. Ubiquitylation of yeast proliferating cell nuclear antigen and its implications for translesion DNA synthesis. Haracska L, Unk I, Prakash L, Prakash S. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6477-82. Epub 2006 Apr 12. PMID: 16611731
  7. Interaction with PCNA is essential for yeast DNA polymerase eta function. Haracska L, Kondratick CM, Unk I, Prakash S, Prakash L. Mol Cell. 2001 Aug;8(2):407-15. PMID: 11545742
  8. Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of abasic sites. Haracska L, Unk I, Johnson RE, Johansson E, Burgers PM, Prakash S, Prakash L. Genes Dev. 2001 Apr 15;15(8):945-54. PMID: 11316789
  9. Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions. Johnson RE*, Washington MT*Haracska L*, Prakash S, Prakash L. (*contributed equally to this work) Nature. 2000 Aug 31;406(6799):1015-9. PMID: 10984059
  10. Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase eta. Haracska L, Yu SL, Johnson RE, Prakash L, Prakash S. Nat Genet. 2000 Aug;25(4):458-61. PMID: 10932195

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