HCEMM-SU Inflammatory Signaling Research Group

Group Leader

Balázs Enyedi

Group Leader

OCCUPATION

Semmelweis University / Hungarian Academy of Sciences / HCEMM Budapest, Hungary
Assistant Professor 2018-current

 

EDUCATION

Semmelweis University Budapest, Hungary
Ph.D. in Cellular and Molecular Physiology, Summa cum laude 2006-2011

Semmelweis University Budapest, Hungary
M.D. Summa cum laude 2000-2006

 

PREVIOUS RESEARCH AND WORK EXPERIENCE

Semmelweis University, Heart and Vascular Center Budapest, Hungary
Cardiology Fellow 2016-2017

Memorial Sloan Kettering Cancer Center New York, NY, USA
Postdoctoral Fellow, Department of Cell Biology 2011-2016
Advisor: Dr. Philipp Niethammer
Topic: Studying inflammatory responses coupled to tissue injury in zebrafish

Semmelweis University Budapest, Hungary
Assistant lecturer, Department of Physiology 2009-2015
Graduate Student, Department of Physiology 2006-2011
Advisor: Miklós Geiszt, M.D., PhD
Thesis: Novel methods for studying hydrogen peroxide-producing mechanisms in mammalian cells

Université de Genève Geneva, Switzerland
EMBO Short term fellow, Department of Cell Physiology and Metabolism Summer 2010
Advisor: Prof. Pierre Maechler, PhD
Topic: Measurement and manipulation of hydrogen peroxide levels in pancreatic beta-cells

Semmelweis University Budapest, Hungary
Undergraduate student, Department of Physiology 2004-2006
Advisor: Miklós Geiszt, M.D., PhD
Topic: Role and source of mitochondrial and endoplasmic reticular hydrogen peroxide production

Semmelweis University Budapest, Hungary
Undergraduate student, Institute of Medical Chemistry 2002-2004
Mentor: Prof. Laszló Buday, M.D. PhD DSc
Topic: Role of cortactin in mediating actin polymerization

National Institutes of Health Bethesda, MD, USA
Summer student, National Institute of Allergy and Infectious Diseases (NIAID) Summer 2002
Mentor: Steven M. Holland, M.D.
Topic: Interferon-gamma receptor 1 promoter polymorphisms

 

RESEARCH FELLOWSHIPS AND SCHOLARSHIPS

Lucille Castori postdoctoral fellowship 2013-2015
EMBO Short term fellowship 2010
National Scholarship of the Hungarian Republic (awarded to top 5 percent of students) 2004-2006
Erasmus Scholarship – Charité, Berlin, Germany 2005

 

RESEARCH GRANTS WON AS RESEARCH GROUP LEADER

Seeding grant of the Hungarian Centre of Excellence for Molecular Medicine (~450.000 USD) 2019-2024
The Hungarian Academy of Sciences, ‘Momentum’ grant (~900.000 USD) 2018-2023
Semmelweis University Core Grant (~60.000 USD) 2017
Semmelweis University R&D Grant (~40.000 USD) 2017
The Hungarian Academy of Sciences, Premium Post Doctorate Research Program (~100.000 USD) 2017-2018
Semmelweis University Startup Grant (~80.000 USD) 2016

 

SCIENTIFIC PRIZES AND AWARDS

Burgen Scholarship Award from the Academia Europaea 2017
Junior Príma Prize – Prima Foundation (Hungary, 10 scientists per year below 33 from all fields of science) 2014
Talented Student Researcher Prize 2006
1st prize at the Hungarian National Research Students’ Conference (OTDK) 2005
2nd prizes in the Physiology and Pathophysiology competitions at the Semmelweis University 2002
1st prizes in the Biochemistry, Biophysics, Anatomy competitions at the Semmelweis University 2001
12th prize in the National Physics Competition for High School Students (OKTV) 2000
7th prize in the National Biology Competition for High School (OKTV) 2000

 

TALKS AND PRESENTATIONS

Semmelweis University – Research Salon 2018
invited speaker
IST Vienna, Life Sciences Semainar 2017
invited speaker
Mechanobiology Session of the Biophysical Society Meeting, Los Angeles, USA 2016
selected talk
Keystone Symposium on Molecular Cell Biology of Macrophages in Human Diseases, Santa Fe, New Mexico 2014
selected talk
Gordon Research Conference on Tissue Regeneration & Repair, New London, NH 2013
selected talk
IUBMB, Cell Signaling Networks, Mérida, Mexico 2011
poster presentation: ASBMB award
Gordon Research Conference on the NOX Family NADPH Oxidases, Les Diablerets, Switzerland 2010
selected talk
IUBMB, Shanghai, China 2009
poster presentation
Gordon Research Conference on the NOX Family NADPH Oxidases, Colby-Sawyer College,New London, NH 2009
poster presentation
FEBS Athens, Greece 2008
poster presentation, selected for Young Scientists’ Forum
Annual Conference of the Hungarian Signal Transduction Society, Hőgyész, Hungary 2003
selected talk

 

TEACHING EXPERIENCE

Semmelweis University undergraduate program 2017-
Supervisor of 2 undergraduate students
Semmelweis University – Medical Physiology course 2017-
Instructor (in German and Hungarian)
Memorial Sloan Kettering Cancer Center 2011-2016
Supervised an MD, PhD student and 4 PhD rotation students
Semmelweis University undergraduate program 2006-2011
Supervisor of 4 undergraduate students
Semmelweis University – Medical Physiology course 2005-2011
Instructor (in German and Hungarian)
Semmelweis University – Medical Physiology course 2004-2005
Teaching Assistant (in German and Hungarian)

 

ROLE IN SCIENTIFIC COMMUNITY

Secretary of the Youth Division of the Hungarian Physiological Society 2018-
Member of the Hungarian Genetics Society 2017-
Member of the Biophysical Society 2016-
Member of the Hungarian Biochemical Society 2008-
Member of the Hungarian Physiological Society 2007-

 

PERSONAL

Languages: Fluent in Hungarian (mother tongue), English and German, working knowledge of French
Programming languages: Intermediate in Python, beginner in Matlab
Interests: Squash, rock climbing, sailing and skiing

Publications

  1. Jelcic M, Enyedi B, Niethammer P.:”Quantitative Imaging of Endogenous and Exogenous H2O2 Gradients in Live Zebrafish Larvae.”, Methods Mol Biol. 2019;1982:283-299. IF: 0.38
  2. Enyedi B, Geiszt M.:” Imaging Intracellular H2O2 with the Genetically Encoded PerFRET and OxyFRET Probes.”, Methods Mol Biol. 2019;1982:275-282. IF: 0.38
  3. Stoddard M, Huang C, Enyedi B, Niethammer P.:”Live imaging of leukocyte recruitment in a zebrafish model of chemical liver injury.”, Sci Rep. 2019 Jan 10;9(1):28. IF: 4.122
  4. Sirokmány G, Kovács HA, Lázár E, Kónya K, Donkó Á, Enyedi B, Grasberger H, Geiszt M. „Peroxidasin-mediated crosslinking of collagen IV is independent of NADPH oxidases.” Redox Biol. 2018 Jun;16:314-321. IF:5.736
  5. Zana M, Péterfi Z, Kovács HA, Tóth ZE, Enyedi B, Morel F, Paclet MH, Donkó Á, Morand S, Leto TL, Geiszt M. ”Interaction between p22phox and Nox4 in the endoplasmic reticulum suggests a unique mechanism of NADPH oxidase complex formation.”, Free Radic Biol Med. 2017 Dec 23. pii: S0891-5849(17)31284-4. IF:5.606
  6. Enyedi B, Niethammer P.: “Nuclear membrane stretch and its role in mechanotransduction.” Nucleus. 2017 Jan 23:1-6. IF: 2.446
  7. Jelcic M*, Enyedi B*, Xavier J., Niethammer P.,” Image-Based Measurement of H2O2 Reaction Diffusion in Wounded Zebrafish Larvae.”, Biophys J. 2017 May 9;112(9):2011-2018. * Equal contribution IF: 3.632
  8. Booth DM, Enyedi B, Geiszt M, Várnai P, Hajnóczky G.: “Redox Nanodomains Are Induced by and Control Calcium Signaling at the ER-Mitochondrial Interface.” Mol Cell. 2016 Jul 21;63(2):240-8. IF: 14.714
  9. Enyedi B, Niethammer P.: “A Case for the Nuclear Membrane as a Mechanotransducer” Cell Mol Bioeng. 2016 Jun;9(2):247-251. IF: 2.535
  10. Enyedi B, Jelcic M, Niethammer P.: “The cell nucleus serves as a mechanotransducer of tissue damage- induced inflammation.” Cell. 2016 May 19;165(5):1160-70 IF: 30.41
  11. Enyedi B, Niethammer P.: “Mechanisms of epithelial wound detection.” Trends Cell Biol. 2015 Jul;25(7):398-407. IF: 11.532
  12. Margittai É, Enyedi B, Csala M, Geiszt M, Bánhegyi G: Composition of the redox environment of the endoplasmic reticulum and sources of hydrogen peroxide. Free Radic Biol Med. 2015 Jun;83:331-40. IF:5.736
  13. Roxbury D, Jena PV, Williams RM, Enyedi B, Niethammer P, Marcet S, Verhaegen M, Blais-Ouellette S, Heller DA.: ”Hyperspectral Microscopy of Near-Infrared Fluorescence Enables 17-Chirality Carbon Nanotube Imaging.” Sci Rep. 2015 Sep 21;5:14167 IF: 5.228
  14. Gault WJ, Enyedi B, Niethammer P.: Osmotic surveillance mediates rapid wound closure through nucleotide release. J. Cell Biol. 2014 Dec 22;207(6):767-82. IF: 9.834
  15. Enyedi B, Kala S, Nikolich-Zugich T, Niethammer P.: Tissue damage detection by osmotic surveillance. Nat Cell Biol. 2013 Sep;15(9):1123–1130. IF: 20.058
  16. Enyedi B, Niethammer P.: H2O2:A chemoattractant? Methods Enzymol. 2013;528:237-55 IF: 2.194
  17. Enyedi B, Melinda Z, Donkó A, Geiszt M.: Spatial and temporal analysis of NADPH oxidase-generated hydrogen peroxide signals by novel fluorescent reporter proteins. Antioxid Redox Signal. 2013 Aug 20;19(6):523-34. IF: 7.667, Cover Story
  18. Fülöp L, Szanda G, Enyedi B, Várnai P, Spät A.: The effect of OPA1 on mitochondrial Ca²+ signaling. PLoS One. 2011;6(9):e25199. IF: 4.092
  19. Donkó A, Ruisanchez E, Orient A, Enyedi B, Kapui R, Péterfi Z, de Deken X, Benyó Z, Geiszt M. : Urothelial cells produce hydrogen peroxide through the activation of Duox1. Free Radic Biol Med. 2010 Dec 15;49(12):2040-8. IF: 5,707
  20. Enyedi B, Varnai P, Geiszt M.: Redox state of the endoplasmic reticulum is controlled by Ero1l-alpha and intraluminal calcium. Antioxid Redox Signal. 2010 Sep 15;13(6):721-9 IF: 8,209, Cover Story
  21. Tőke, J.; Czirják, G.; Patócs, A.; Enyedi, B.; Gergics, P.; Csákváry, V.; Enyedi, P.; Tóth, M.: Neonatal severe hyperparathyroidism associated with a novel de novo heterozygous R551K inactivating mutation and a heterozygous A986S polymorphism of the calcium-sensing receptor gene. Clin Endocrinol (Oxf). 2007 Sep;67(3):385-92. IF: 3.370
  22. Illes, A., B. Enyedi, P. Tamas, A. Balazs, G. Bogel, Melinda, Lukacs, and L. Buday. : ”Cortactin is required for integrin-mediated cell spreading.” Immunol Lett. 2006 Apr 15;104(1-2):124-30. IF: 2.352
  23. Illes A, Enyedi B, Tamas P, Balazs A, Bogel G, Buday L. : “Inducible phosphorylation of cortactin is not necessary for cortactin-mediated actin polymerisation.” Cell Signal. 2006 Jun;18(6):830-40. IF: 4.887
  24. Rosenzweig, S. D., Schaffer, A. A., Ding, L., Sullivan, R., Enyedi, B., Yim, J. J., Cook, J. L., Musser, J. M., Holland, S. M : “Interferon-gamma receptor 1 promoter polymorphisms: population distribution and functional implications.” Clin Immunol. 2004 Jul;112(1):113-9. IF: 3.034

Scientometrics – Impact factor: 163, Citations: ~520, H-index: 13

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